中药复方JEYS溶石和利胆作用研究  

A Research on Litholytic and Choleretic Effects of JEYS,A Traditional Chinese Compound

作　　者：胡勇[1] 周大颖[2] 李淑芳[3] 刘迪成[4] 

机构地区：[1]贵阳医学院公共卫生学院,贵州贵阳550004 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002 [3]贵阳医学院药理学教研室,贵州贵阳550004 [4]贵阳医学院生理学教研室,贵州贵阳550004

出　　处：《贵阳医学院学报》2008年第2期151-154,共4页Journal of Guiyang Medical College

摘　　要：目的:观察中药复方JEYS的溶石和利胆作用。方法:取同一病人的多发性胆石标本随机分为生理盐水组,JEYS低、高剂量组及阳性对照组,用试管法溶石;用豚鼠胆道插管法进行利胆实验,实验分组同溶石组。观察给药前30min,给药后30,60和90min的胆汁流量;检测胆汁中钙离子、总胆固醇和总胆红素的含量。结果:中药复方JEYS有明显的体外溶石作用,且溶石液中的钙离子浓度和总胆红素浓度均明显升高;中药复方JEYS可以明显增加单位时间的胆汁流量及胆汁流量增加百分率,且各给药组中的总胆红素、总胆固醇和钙离子的含量均不同程度降低。结论:中药复方JEYS有体外溶解胆结石的作用,有利胆和降低胆汁中钙离子、总胆红素和总胆固醇的作用。Objective： To observe litholytic and choleretic effects of JEYS, a traditional Chinese compound. Methods Tube method was adopted in litholytic experiment. Gallstones coming from the same patient were divided into four groups and soaked in different solutions： NS, Danshitong solution, and 2 JEYS solutions （low and high doses） ; Cholagogue effects was observed with method of intubaring in cobaya＂ bile duct. Thirty-two guinea pigs were randomly divided into four groups NS group, positive group and JEYS low, high dose groups, The amounts of bile flow, bile Ca^2＋ , total cholester- ol, and total bilirubin were checked at 30min before, and 30min, 60min, and 90min after the treatment. Results Concentrations of Ca^2＋ and total bilirubin were significantly higher in JEYS solutions than those in NS solution; Bile flow per time unit and its increasing rate were significantly higher, and the amounts of total bilirubin, total cholesterol and Ca^2＋ were lower in JEYS treated animals than those in animals of NS group. Conclusions JEYS has litholytic effect in vitro; JEYS has choleretic effect and could decrease Ca^2＋ , total bilirubin, and total cholesterol in biles.

关 键 词：中药复方JEYS 胆结石 利胆 胆红素 钙 胆固醇 胆汁 

分 类 号：R285.5[医药卫生—中药学] R657.42[医药卫生—中医学]