血尿酸水平与老年高血压患者颈动脉硬化关系探讨  被引量:10

A Study on the Relationship between Serum Uric Acid Level and Carotid Atherosclerosis in Elderly Hypertension Patients

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作  者:杨俊[1] 唐海滨[1] 胡艳文[1] 贾豫黔[1] 

机构地区:[1]贵阳市第四人民医院,贵州贵阳550002

出  处:《贵阳医学院学报》2008年第2期159-161,共3页Journal of Guiyang Medical College

摘  要:目的:探讨血尿酸(UA)与老年高血压患者颈动脉粥样硬化病变的关系。方法:将90例老年高血压患者按血UA水平分为A组(血UA<300μmol/L)23例,B组(血UA300~399μmol/L)25例,C组(血UA400~499μmol/L)23例,D组(血UA>500μmol/L)19例,20例血UA<300μmol/L的正常老年人为对照(对照组),应用彩色多普勒超声检测其颈动脉内中膜厚度(IMT)、粥样硬化斑块,同时检测血脂、UA及C反应蛋白(CRP)。结果:高血压组的IMT较对照组明显增厚,P<0.01;动脉粥样斑块的检出率明显增高,P<0.05;且血UA高的高血压患者的IMT较血UA正常的高血压者明显增厚(P<0.05)。结论:高UA高血压、及脂质代谢紊乱均是颈动脉粥样硬化的危险因素。Objective: To study the relationship between carotid artery atherosclerosis and blood uric acid (UA) in the elderly patient's with hypertension. Methods: According to the blood UA levels, 90 hypertension patients were divided into four groups: group A (UA 〈 300μmol/L, n = 23 ), group B (300 〈 UA 〈 399 μmol/L, n = 25 ), group C (400 〈 UA 〈 499 μmol/L, n = 23 ), and group D ( UA 〉 500μmol/L, n = 19). Twenty elderly patients (UA 〈 300μmol/L) without disorder of lipid metabolism or heart and cerebral vessele diseases were chosen as control group. The intima-media (IM) thickness and atherosclerotic plaque (AP) in carotid artery were checked with color Doppler ultrasound, and the blood fats, UA and C-response protein (CRP) were tested at the same time. Results: IM was thicker and the detection rate of AP was higher significantly in patients of hypertension groups than those in people of control group (P 〈 0. 01, and P 〈 0. 05 ). IM in hypertension patients with high-UA was obviously thicker than that of hypertension patients with normal blood UA levels (P 〈 0. 05 ). Conclusion: High uric acid, high blood pressure and lipid metabolism disorders are risk factors to carotid atherosclerosis.

关 键 词:高血压 老年人 尿酸 动脉硬化 

分 类 号:R544.1[医药卫生—心血管疾病] R466.122.9[医药卫生—内科学]

 

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