妊娠高血压综合征患者检测D-二聚体及一氧化氮的临床意义  

Clinical significance of detection of D-dimer and nitric oxide in patients with pregnancy-induced hypertension

作　　者：胡恩赑[1] 刘刚[1] 宋尉[1] 张漩[1] 

机构地区：[1]安徽省蚌埠市第三人民医院检验科,233000

出　　处：《淮海医药》2008年第3期213-214,共2页Journal of Huaihai Medicine

摘　　要：目的探讨妊娠高血压综合征患者D-二聚体及一氧化氮检测的临床意义。方法检测61例妊娠期高血压患者、27例正常晚期妊娠孕妇和30例正常非妊娠妇女D二-聚体及一氧化氮的水平。结果妊娠期高血压患者组血浆D-二聚体水平明显高于正常晚期妊娠组(P<0.01),血浆D-二聚体水平越高,妊娠期高血压病情越重。妊娠期高血压组血清一氧化氮水平明显低于正常晚期妊娠组(P<0.01),血清一氧化氨水平与妊娠期高血压严重程度无明显相关性。结论血浆D二-聚体水平升高、血清一氧化氮水平下降与妊娠期高血压综合征发病有关。Objective To study the clinical significance of D-dimer and nitric oxide levels in patients with pregnancy-induced hypertension （PIH）. Methods D-dimer and NO levels of 61 women with PIH,27 normal pregnant women and nonpregnant women were measured. Results D-dimer level in patients with PIH was significantly higher than those in normal pregnant women （P 〈 0. 01 ）. The higher D-dimer level is, the more severe PIH is. NO level was significantly lower in patients with PIH than normal pregnant women （P 〈 0.01 ）. There was no obvious correlation between NO level and severeness of PIH. Conclusion The tendency of increased D-dimer level and declined NO level may play a role in the pathogenesis of PIH.

关 键 词：高血压 妊娠性 D-二聚体 一氧化氮 

分 类 号：R446.1[医药卫生—诊断学]