肺炎衣原体感染与急性心肌梗死关系的研究  

Relation between Chlamydia pneumoniae infection and acute myocardial infarction

作　　者：关秀茹[1] 马学华[1] 赵宇[1] 蒋丽鑫[1] 张萱[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院实验诊断教研室,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2008年第2期160-162,共3页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金项目(D200613);黑龙江省卫生厅资助项目(2006-058)

摘　　要：目的探讨肺炎衣原体感染与急性心肌梗死之间的关系。方法采用ELISA方法检测78例急性心肌梗死患者与80例正常对照组血清中肺炎衣原体IgG抗体水平,同时检测两组的IL-6、ET-1、sVCAM-1、hsCRP水平。结果急性心肌梗死组肺炎衣原体IgG抗体阳性率(58.97%)显著高于对照组(41.25%,P<0.05)。急性心肌梗死组IL-6(69.08±108.29)、ET-1(50.87±28.66)s、VCAM-1(30.03±25.86)、hsCRP(23.80±33.44)水平与对照组(22.91±17.37,31.59±9.09,5.53±5.37,2.10±1.79)比较差异有统计学意义(P<0.01)。结论肺炎衣原体感染可能通过激发和加重冠状动脉内炎症反应,参与动脉粥样硬化、急性心肌梗死的病理过程。Objective To study the correlation between Chlamydia pneumoniae infection and acute myocardial infarction（AMI）.Methods Chlamydia pneumoniae IgG antibody in 78 patients AMI and 80 normal controls were measured by ELISA.The levels of interleukin-6（IL-6）,endothelin-1（ET-1）,soluble vascular cell adhesion molecule-1（sVCAM-1） and hypersensitive C-reactive protein（hsCRP） were also examined.Results The positive rates of Chlamydia pneumoniae IgG antibody（58.97%）in AMI group were significantly higher than that in control（41.25%;P〈0.05）.The concentrations of IL-6（69.08±108.29）,ET-1（50.87±28.66）,sVCAM-1 （30.03±25.86） and hsCRP（23.80±33.44） in AMI group were all higher than those（22.91±17.37,31.59±9.09,5.53±5.37,2.10±1.79） in control group（all P〈0.01）.Conclusion There is significant correlation between Chlamydia pneumoniae infection and AMI.Chlamydia pneumoniae infection may be involved in the pathogenesis of atherosclerosis and AMI by inducing and accelerating coronary artery inflammation.

关 键 词：肺炎衣原体 动脉粥样硬化 急性心肌梗死 细胞因子 

分 类 号：R542.22[医药卫生—心血管疾病] R374.3[医药卫生—内科学]