原发性高血压对循环内皮祖细胞的影响  

Influence of Essential Hypertension on Circulating Endothelial Progenitor Cells

作　　者：鲁力[1] 周建中[1] 张铁须[1] 王珍[1] 杭丽玮[1] 

机构地区：[1]重庆医科大学附属第一医院心内科,重庆市400016

出　　处：《中国全科医学》2008年第9期744-746,共3页Chinese General Practice

摘　　要：目的探讨原发性高血压和循环内皮祖细胞(CEPCs)的关系及血压控制对CEPCs的影响。方法选取原发性高血压患者30例,包括血压未控制者和血压控制达标者各15例,并选取15例健康成人为正常对照。采集外周血进行CEPCs的分离、培养,测定CEPCs的数量、增殖能力、黏附能力及凋亡率,并进行比较分析。结果血压控制达标组和血压未控制组的CEPCs数量、凋亡率、增殖能力和黏附能力与正常对照组间差异均有统计学意义(P<0.01);血压未控制组与血压控制达标组的CEPCs数量、凋亡率、增殖能力间差异均有统计学意义(P<0.01),黏附能力间差异无统计学意义(P>0.05)。结论原发性高血压患者CEPCs受损;在规范服用降压药物控制血压达标的基础上,联合应用能够增加CEPCs数目、改善其功能的药物,可能会使原发性高血压患者获取降压外的效益。Objective To investigate the relationship between essential hypertension and circulating endothelial progenitor cells （CEPCs） and the influence of blood pressure control on CEPCs. Methods Fifteen uncontrolled and fifteen controlled essential hypertensive patients were enrolled, with fifteen healthy subjects as the controls. CEPCs were isolated from peripheral blood and cultivated in vitro. The number, proliferation power, adhesion ability and apoptosis rate of CEPCs were comparatively analyzed after seven days cultivation. Results Compared with healthy group, both controlled and uncontrolled essen- tial hypertension groups showed significant differences in the apoptosis rate, CEPCs＇ number proliferation power and adhesion ability （ P 〈 0. 01 ）. Between the controlled essential hypertension group and uncontrolled essential hypertension group, there were significant differences in number, apoptosis rate and proliferation power of CEPCs （ P 〈 0. 01 ）, but there was no significant difference in adhesion ability （ P 〉 0. 05 ）. Conclusion The CEPCs in essential hypertension patients essential hypertension patients are damaged. The therapy of antihypertensive drugs combined with drugs which could increase CEPCs number and improve CEPCs function in essential hypertensive patients might have additional benefit.

关 键 词：高血压 内皮祖细胞 细胞凋亡 

分 类 号：R544.11[医药卫生—心血管疾病]