复脾汤对STZ大鼠SOD、LPO影响的实验研究  

The Effect of Fu-Spleen Decoction on the SOD and LPO of STZ Rats

作　　者：郑仲华 李玲[2] 曾庆明 

机构地区：[1]郑州市中医院,河南郑州450007 [2]河南省中医药研究院附属医院,河南郑州450004 [3]桐柏县卫生学校,河南桐柏474750

出　　处：《河南中医学院学报》2008年第3期16-18,共3页Journal of Henan University of Chinese Medicine

摘　　要：目的:观察复脾汤对STZ大鼠血糖、超氧化物歧化酶(SOD)、过氧化脂质(LPO)等指标的影响。方法:采用链脲佐菌素(STZ)腹腔注射制备糖尿病大鼠模型,随机分为5组,以美吡达为阳性对照,与预防给药组(预防组)和正常给药组(复脾组)进行对比研究。结果:各组血糖的变化率相比,模型组与正常组相比有显著性差异(P<0.01),各用药组与模型组相比有显著性差异(P<0.01),复脾组与预防组的血糖变化率与西药组比较有显著性差异(P<0.01)。第4周末SOD、LPO水平比较,预防组和复脾组与模型组、美吡达组相比均有差异(P<0.05,P<0.01)。结论:复脾汤能够降低血糖、过氧化脂质水平,升高超氧化物歧化酶水平,预防组较复脾组疗效更显著。Objective： to observe the effect of Fu-spleen decoction on the SOD and LPO of STZ rats, Method： the diabetes model was induced by STZ peritoneal injection and the rats were divided five groups. The mindiab was the positive control. Results： there was significant difference between model and control in blood sugar change（P 〈 0.01 ）and significant difference between model and Medication groups（P〈 0.01 ）and significant difference between Fu-spleen decoction and prophylaxis groups and western medicine group（P 〈0.01 ）. SOD and LPO had the significant difference between Fu-spleen decoction and prophylaxis groups and model and mindiab groups（P 〈 0.05, P〈 0.01 ）. Conclusion： the Fu-spleen decoction has the function to degrade the blood sugar and LPO level.

关 键 词：复脾汤 糖尿病 脾胃 健脾益气养阴 超氧化物歧化酶 过氧化脂质 

分 类 号：R285.5[医药卫生—中药学]