方格星虫提取物的抗辐射作用  

Protective effect of Sipunculus nudus preparation on mouse irradiated by ^(60)Co

作　　者：沈先荣[1] 蒋定文[1] 陆敏[1] 陈伟[1] 栾洁[1] 杨翊方[1] 张建国[1] 

机构地区：[1]海军医学研究所,上海200433

出　　处：《中国海洋药物》2008年第2期33-36,共4页Chinese Journal of Marine Drugs

摘　　要：目的研究方格星虫提取物的抗辐射作用。方法将50只ICR雄性小鼠随机分为对照组、模型组及低、中、高3个方格星虫提取物组,灌胃给药,每天1次,给药第15d,以60Coγ射线进行全身照射一次,照射剂量为5Gy,照后继续给药14d。测定小鼠外周血白细胞、血小板和血细胞计数,脾指数、胸腺指数、骨髓有核细胞计数、血清SOD活性和MDA含量,以及睾丸指数、精子数、精子畸形率等。结果与模型组比较,方格星虫3个剂量组白细胞数、红细胞数、骨髓有核细胞数升高显著;胸腺脾和睾丸指数显著升高;精子数上升,精子畸形率下降,SOD活力增高,而MAD含量下降。结论方格星虫提取物具有显著的抗辐射作用。Objective To evaluate the protective effects of Sipunculus nudus preparation （SNP） on mice irradiated by 60^Co. Methods The mice were divided into control group,model group and 0.5, 1.0, and 2.0g · kg-1 · d^-1SNP groups. SNP was administrated by intra-gastric infusion with the volume of 0.4mL per 20g. In the fifteenth day,the model group and the treated groups were irradiated by γ-ray of 60^Co（0. 83Gy/h） with the dose of 5 Gy. Peripheral blood WBC, RBC, PLT, the spleen （SI） and thymus index（TI）, the BMNC, SOD and MDA in serum,testicle index, germ cells were detected. Results Comparing with the model group,TI, SI and peripheral blood WBC, RBC and BMNCs were higher. The activities of SOD in serum were increased,while MDA decreased. Testicle index and germ cells were increased, and germ abnomality rate was decreased in SNP groups. Conclusion SNP has protective effects on mice irradiatied by 60^Co.

关 键 词：方格星虫 免疫调节 辐射防护 

分 类 号：Q959.19[生物学—动物学] R965[医药卫生—药理学]