灵雷菌质的急性毒性实验研究  

Experimental Study of the Acute Toxicity of Fungal Fermentation Substance on Tripterygium

作　　者：王卫倩[1] 戴丹丹[1] 罗闳丹[1] 庄毅[1] 谢小梅[1] 

机构地区：[1]江西中医学院菌物药研究中心,江西南昌330004

出　　处：《中国食用菌》2008年第3期36-38,共3页Edible Fungi of China

基　　金：科技部国际合作项目(雷公藤固体发酵减毒持效的研究);项目编号:(2006DFA33060)

摘　　要：研究双向性固体发酵后灵雷菌质的急性毒性。用双向性固体发酵技术获得灵雷菌质,用Bliss法计算小鼠的半数致死量(LD5)0。结果表明各灵雷菌质组的LD50均高于雷公藤生药组,尤以3G30组最高。双向性固体发酵技术可降低雷公藤的急性毒性。To survey the acute toxicity of the fungal fermentation substance on Tripterygium. The modified Tripterygium wilfordii Hook was obtained by a novel bi-directional solid-state fermentation, Bliss method was used to calculate the lethal dose of 50% （LD50） of the fungal fermentation substance on Tripterygium in mice . The LD50 of the fungal fermentation substance on Tripterygium was higher than the raw materials, the 3G30 is the highest. The acute toxicity of Tripterygium wilfordii Hook could be reduced by bi-direction solid-state fermentation.

关 键 词：雷公藤 双向固体发酵 灵雷菌质 LD50 

分 类 号：R285[医药卫生—中药学]