HLA与光敏性皮肤病  

HLA and photosensitive dermatosis

作　　者：苏顺琴[1] 何黎[1] 

机构地区：[1]昆明医学院第一附属医院皮肤科,650031

出　　处：《国际皮肤性病学杂志》2008年第3期172-174,共3页International Journal of Dermatology and Venereology

摘　　要：HLA是人类最为复杂的基因多态性遗传系统，其所编码的Ⅰ类分子和Ⅱ类分子主要参与对抗原肽的处理。光敏性皮肤病的发病机制尚不清楚，目前认为其是机体对紫外线照射所引起的一种未知抗原的超敏反应，而机体对抗原的免疫应答都需要HLA的参与。因此，HLA基因的表达与光敏性皮肤病的发病密切相关。HLA is known to be the most polymorphic genetic system in human. HLA class Ⅰ and Ⅱ molecules coded by this system mainly take part in the processing of peptide antigens. On one hand, the mechanisms of photosensitive dermatosis remain unclear, and are presumed to be a hypersensitivity response to unknown antigen associated with the radiation of ultraviolet ray. On the other hand, HLA is required for all the immune response. So, the pathogenesis of photosensitive dermatosis is closely related to the expression of HLA.

关 键 词：HLA抗原 皮炎 光变态反应 皮肤表现 

分 类 号：R758.1[医药卫生—皮肤病学与性病学]