尿铜蓝蛋白与糖尿病肾病关系的研究  

Relationship between urinary ceruloplasmin and diabetic nephropathy

作　　者：谢英才[1] 陈文璞[1] 洪夏晓[1] 

机构地区：[1]广东医学院附属医院内分泌科,湛江524001

出　　处：《中国医师进修杂志（内科版）》2008年第5期5-7,共3页Chinese Journal of Postgraduates of Medicine

基　　金：广东省湛江市科技计划项目（2006C03008）

摘　　要：目的研究尿铜蓝蛋白（CP）与糖尿病肾病（DN）的关系。方法将236例2型糖尿病患者分为正常白蛋白（Alb）尿组（DMN组）129例，微量Alb尿组（DMMA组）107例，另选择81例健康体检者作为对照组（C组）。检测尿CP、Alb、肌酐（Cr）和血清CP等。结果（1）尿CP／Cr中位数在DMMA组为2．55ng／mmol，在DMN组为1．18ng／mmol，均显著高于C组0．92ng／mmol，P〈0．01；血清CP在各组间比较差异均无统计学意义（P〉0．05）。（2）2型糖尿病患者尿Mb／Cr与尿CP／Cr呈显著正相关（r=0．188，P〈0．01），糖尿病病程为尿CP／Cr和Alb／Cr升高的危险因素。结论2型糖尿病患者尿CP与尿Alb排泄量有一致性升高的趋势。2型糖尿病患者尿CP升高，其与DN的发生和严重程度有较好的相关性，尿CP可以用来监测DN的发生，病情进展和治疗效果。Objective To study the relationship between urinary ceruloplasmin（CP）and diabetic nephropathy. Methods Two hundred and thirty-six patients with type 2 diabetes meUitus were divided into normal albuminuria group （DMN group, 129 cases） and micro-albuminuria group （DMMA group, 107 cases）.Eighty-one healthy people were admitted into control group. The levels of urinary CP,serum CP, urinary albumin（Alb）and urinary creatinine（Cr）were measured. Results The median of urinary CP/Cr in DMMA group （2.55 ng/mmol） and DMN group （1.18 ng/mmol ）was higher than that in control group （ 0.92 ng/mmol） （P 〈 0.01 ）. There was no significant difference in the levels of sen, m CP in each group （P 〉 0.05 ）. The urinary Alb/Cr was significantly positively correlated with urinary CP/Cr （r = 0.188 ,P 〈 0.01 ）in patients with type 2 diabetes mellitus. The course of diabetes mellitus was a risk factor of urinary CP/Cr and Alb/Cr increase. Conclusions The urinary CP shows increasing tendency in accord with urinary Alb in type 2 diabetes mellitus patients. Urinary CP elevates obviously and correlates with diabetic nephropathy. Urinary CP may be used to monitor the onset, progress and therapeutic effect of diabetic nephropathy.

关 键 词：铜蓝蛋白 糖尿病肾病 白蛋白尿 

分 类 号：R587.2[医药卫生—内分泌] R692.507[医药卫生—内科学]