检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:张天弼[1] 肖芸[2] 冯慧斌[1] 杜雪霞[1] 陈小龙[1] 涂相华[1] 吴明清[1]
机构地区:[1]汕头大学医学院附属粤北人民医院综合内科,广东韶关512026 [2]汕头大学医学院附属粤北人民医院呼吸内科,广东韶关512026
出 处:《中国医师进修杂志(内科版)》2008年第5期15-17,共3页Chinese Journal of Postgraduates of Medicine
摘 要:目的探讨COPD急性加重期患者外周血中CD4^+CD25^+调节性T细胞及CRP水平的变化及意义。方法以36例COPD急性加重期患者(COPD组)和36例COPD稳定期患者(对照组一)及36例健康人(对照组二)作为研究对象,采用流式细胞技术检测三组外周血中CD4^+CD25^+调节性T细胞的表达水平,并常规检测血清CRP水平。结果COPD组外周血中CD4^+CD25^+占CD4^+T细胞的百分比为(2.56±1.83)%,明显低于对照组一和对照组二(P均〈0.01);COPD组CRP水平为(55.7±14.8)mg/L,明显高于对照组一和对照组二(P均〈0.01)。CD4^+CD25^+调节性T细胞表达水平与CRP水平呈负相关(r=-0.312,P〈0.05)。结论CD4^+CD25^+调节性T细胞比例减少导致COPD急性加重期患者细胞免疫失调,CRP参与了炎性反应激活过程,可能为COPD急性加重期免疫治疗提供理论依据。Objective To study the changes and significance of CD4^+CD25^+ regulatory T cells and C-reactive protein (CRP) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Flow cytometry was used to detect the frequency of CD4^+CD25^+ regulatory T cells in peripheral blood from 36 patients with acute exacerbation of COPD ( COPD group) and 36 patients with clinical stability of COPD (control group one )and 36 normal individuals (control group two). The level of CRP was detected routinely. Results The ratio of CD4^+CD25^+ regulatory T cells number in peripheral blood of COPD group to the total number of CD4^+ T cell was (2.56 ± 1.83 )%, and it was significanlly decreased compared to the other two groups (P all 〈 0.01 ). The level of CRP in COPD group was markedly higher than that in the other two groups (Pall 〈 0.01 ). The level of CD4^+CD25^+ regulatory T cells in patients with acute exacerbation of COPD had negative relation with CRP. Condusions CD4^+CD25^+ regulatory T cells participate in inflammatory response. The proportion of CD4^+CD25^+ regulatory T ceils decreases in patients with acute exacerbation of COPD, and it may result in maladjustment ofcytoimmunity.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.200