嗜酸粒细胞性支气管炎的临床探讨  

The clinical exploration of eosinophilic bronchitis

作　　者：林隆[1] 

机构地区：[1]首都医科大学附属北京天坛医院呼吸内科,100078

出　　处：《中国医师进修杂志（内科版）》2008年第5期24-26,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的研究嗜酸粒细胞性支气管炎（EB）患者的气道炎性反应特点。方法对7例EB患者（EB组）行诱导痰嗜酸粒细胞计数，并与12例哮喘患者（哮喘组）、16例咳嗽变异性哮喘（CVA）患者（CVA组）和6例变应性鼻炎患者（变应性鼻炎组）进行对照。计算诱导痰中嗜酸粒细胞比例及EB组和CVA组患者支气管黏膜活检嗜酸粒细胞、肥大细胞计数。结果哮喘组诱导痰中嗜酸粒细胞比例为（18．7±5．3）％，CVA组为（10．2±4．5）％，EB组为（8．7±2．3）％，变应性鼻炎组为（2．7±3．2）％。EB组与哮喘组、CVA组、变应性鼻炎组嗜酸粒细胞比例比较，差异均有统计学意义（P均〈0．05）。CVA组嗜酸粒细胞和肥大细胞分别为（5．2±1．2）个／mm^2和（12．5±2．4）个／mm^2；EB组分别为（1．3±0．1）个／mm^2和（3．5±1．4）个／mm^2，两项指标两组比较，差异均有统计学意义（P均〈0．05）。结论EB可能与多种疾病有关，积极治疗可能阻止其进一步发展为哮喘；EB患者嗜酸粒细胞、肥大细胞的浸润数量较CVA明显减少，可能是其缺乏气道高反应的重要原因。Objective To explore the features of airway inflammation in patients with eosinophilic bronchitis （EB）. Methods Sputum induced eosinophilic count was performed in 7 patients with EB （EB group）, 12 patients with asthma（asthma group）, 16 patients with cough variant asthma（CVA group）, and 6 patients with atrophic rhinitis（ AR group）. The number of eosinophil and mastocyte was detected by bronchial biopsy in patients of EB and CVA group. Results The percentage of eosinophil counts of induced sputum in asthma group, CVA group, EB group and AR group was （ 18.7 ± 5.3 ）%, （ 10.2 ± 4.5）% ,（ 8.7 ± 2.3）% and （2.7 ± 3.2）% respectively. There were significant differences between EB group and the other three groups, The number of eosinophil in airway smooth muscle was significantly lower in EB group [ （ 1.3 ± 0.1 ）/mm^2 ] than that in CVA group[ （5.2 ± 1.2）/mm^2]. And the mastocyte number in EB group[ （3.5 ± 1.4）/mm^2] was significantly lower than that in CVA group [ （ 12.5 ± 2.4）/mm^2]. Conclusions Perhaps EB is associated with many diseases. Aggressive treatment maybe prevent asthma. Eosinophil and mastocyte number is significantly low in patients with EB compared those with CVA, which maybe play an important role in absent airway hyper-responsiveness in EB.

关 键 词：嗜酸粒细胞性支气管炎 气道 症状 治疗方法 

分 类 号：R562.21[医药卫生—呼吸系统]