Human TSLP-Educated DCs  

作　　者：Jiongkun Wang Feiyue Xing 

机构地区：[1]Institute of Tissue Transplantation and Immunology, Jinan University,Guangzhou 510632, China

出　　处：《Cellular & Molecular Immunology》2008年第2期99-106,共8页中国免疫学杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.30471635);the Natural Science Foundation of Guangdong Province in China(No.04010451 and No.5006033).

摘　　要：Thymic stromal lymphopoietin （TSLP）, an IL-7-related cytokine, is widely expressed by epithelial cells in many tissues with different biological effects. Human TSLP （hTSLP） has been shown to play an important role in promoting T cell homeostasis, developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to hTSLP, dendritic cells （DCs） are the most obviously characterized target cells. In this review, we attempt to outline an effect of the functional versatility of hTSLP-activated DCs （hTSLP-DCs） on T cells. Cellular ＆ Molecular Immunology.Thymic stromal lymphopoietin （TSLP）, an IL-7-related cytokine, is widely expressed by epithelial cells in many tissues with different biological effects. Human TSLP （hTSLP） has been shown to play an important role in promoting T cell homeostasis, developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to hTSLP, dendritic cells （DCs） are the most obviously characterized target cells. In this review, we attempt to outline an effect of the functional versatility of hTSLP-activated DCs （hTSLP-DCs） on T cells. Cellular ＆ Molecular Immunology.

关 键 词：thymic stromal lymphopoietin OX40 ligand dendritic cell T cell 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]