氨甲喋呤治疗输卵管妊娠两种途径的临床观察  

Two pathways of methotrexate administration to treat oviductal pregnancy

作　　者：范波[1] 姜荣娅[1] 

机构地区：[1]川北医学院附院妇产科,四川南充637000

出　　处：《西部医学》2008年第3期575-577,共3页Medical Journal of West China

摘　　要：目的探讨MTX治疗输卵管妊娠的两种途径中哪种更安全、有效。方法选择早期未破裂型输卵管妊娠220例,其中120例采取放射介入技术向输卵管病灶内注入MTX 2 mg/kg。另100例采用肌肉注射MTX 2 mg/kg。密切观察生命体征,治疗反应,阴道B超和血βHCG的变化。结果放射介入治疗的患者,116例成功,治愈率达96.7%;肌肉注射治疗的患者,87例成功,治愈率达87.0%,放射介入疗效显著(χ2=7.148,P=0.008)。结论放射介入治疗优于肌肉注射治疗,它是一种安全,有效的治疗未破裂型输卵管妊娠的方法。Objective To investigate the appropriate methotrexate- administrated ways to treat oviductal pregnancy. Methods 220 patients with primary oviductal pregnancy before rupture were taken into the trial, in whom 120 patients were injected with methotrexate 2mg/kg into the affected oviduct by radio interventional technique, while the other 100 patients were injected MTX2mg/kg intramuscularly. The vital signs and therapeutic reaction were observed. B-ultrasound and blood βHCG were examined. Results In radio interventional group, 116 patients achieved success, 4 failed, and the cure rate was 96. 7%. In muscular injection group, 87 patients were successeful,13 failed, and the cure rate was 87% （χ^2= 7. 148,P=0. 008）. Conclusion Radio interventional therapy is superior to muscular injection. It is a safe and effective pathway used in the treatment of primary oviductal pregnancy before rupture.

关 键 词：MTX 输卵管妊娠 放射介入 肌肉注射 

分 类 号：R714.221[医药卫生—妇产科学]