2型糖尿病合并胃轻瘫患者的动态血糖谱  

Continuous glucose monitoring in type 2 diabetes with gastroparesis

作　　者：曾文衡[1] 何晓雯[1] 沈洁[1] 谷卫[1] 

机构地区：[1]浙江大学医学院附属第二医院内分泌科,杭州310009

出　　处：《中华内科杂志》2008年第5期397-400,共4页Chinese Journal of Internal Medicine

基　　金：浙江省科技厅课题（2005 491020-J30527）;礼来公司横向合作课题（2004 491020-140439）

摘　　要：目的探讨2型糖尿病合并胃轻瘫患者的动态血糖特征。方法对31例2型糖尿病患者以核素扫描评估胃排空，并以7例正常糖调节者作对照；所有人组对象在平衡饮食状态下用动态血糖监测系统（CGMS）进行72h血糖监测。结果31例2型糖尿病患者中胃轻瘫占58．1％。胃轻瘫组和非胃轻瘫组在早餐后2h平均血糖值[（7．82±1．42）mmol／L比（9．35±2．28）mmol／L]、早餐后血糖最高值[（10．21±2．17）mmol／L比（12．24±2．82mmol／L）]和2h平均血糖曲线下面积[（877．62±272．78）min·mmol·L^-1比（1028．40±283．98）min·mmol·L^-1]，差异具有统计学意义（P〈0．05）。结论2型糖尿病胃轻瘫患者胃排空延迟可能有助于降低餐后平均血糖。Objective To observe the glucose profile in type 2 diabetic gastroparesis. Methods 31 patients diagnosed with type 2 diabetes were enrolled into this study for measurement of gastric emptying of solids and continuous glucose monitoring to observe blood glucose levels for 72 hours on a balanced diet; the results were compared with 7 subjects with normal glucose regulation. Results 58.1% of 31 type 2 diabetic patients were found to have delayed gastric emptying of solids. The average glucose level was lower after breakfast[（7.82 ± 1.42） mmol/L vs（9.35 ±2.28） mmol/L, P 〈 0.01] in the patients with gastroparesis than in those without. Maximal blood glucose level after breakfast[ （ 10. 21 ±2. 17） mmol/L vs （ 12. 24 ±2. 82 ） mmol/L, P 〈0. 01 ]was lower in the patients with gastroparesis but it reached the peak at a similar time. Two hour AUC was also lower after breakfast in the patients with gastroparesis [ （ 877.62 ± 272.78）min ·mmol·L^-1 vs（1028.40 ±283.98）min·mmol·L^-1, P 〈 0.05]. Conclusion Post-prandial glucose level in type 2 diabetic patients with gastroparesis tends to be lower than those without.

关 键 词：糖尿病 2型 胃排空 动态血糖监测 

分 类 号：R686[医药卫生—骨科学]