Lisinopril在碳糊电极上的电化学性质及电分析  

Electrochemical Behavior of Lisinopril at Carbon Paste Electrode and Its Electroanalytical Application

作　　者：犹卫[1] 郑志祥[1] 高作宁[1] 

机构地区：[1]宁夏大学能源化工重点实验室,化学化工学院银川750021

出　　处：《应用化学》2008年第5期578-582,共5页Chinese Journal of Applied Chemistry

基　　金：宁夏高等学校科学研究基金(200623);宁夏大学自然科学基金(ZR0641)资助项目

摘　　要：运用循环伏安法（CV），计时电流法（CA）和计时电量法（CC）研究了赖诺谱利（Lisinopril，KSP）在碳糊电极（CPE）上的电化学行为及其电化学动力学性质。研究结果表明，LSP在CPE上的电化学过程是不可逆电化学氧化过程，氧化峰电位Ep=0．956V。在10～1000mV／s扫描速率范围内，其氧化峰电流与扫描速度平方根（v^1／2）呈良好的线性关系，表明LSP在CPE上的伏安行为是一受扩散控制的电极过程。用方波伏安法（SWV）考察了KSP氧化峰电流与浓度之间的关系，氧化峰电流与其浓度在1．0×10^-6～5．6×10^-3mol／L范围内呈良好的线性关系，相关系数R=0．9998，检出限5．0×10^-7mol／L，RSD为1．9％～2．3％，加样回收率为98％～102％．据此建立了LSP含量的电化学测定方法。Electrochemical behavior and electrochemical kinetic parameters of LSP at carbon paste electrode （CPE） were investigated by cyclic vohammetry （ CV ）, chronoamperometry （ CA ）, and chronocoulometry （CC）. Electrochemical experimental results showed that LSP in 0. 10 mol/L PBS exhibited an irreversible electrochemical redox process at CPE, and the oxidation peak potential （Epa） was 0. 956 V. The plots of oxidation peak current versus the square root of the scanning rate for the redox in a potential range of 10 1 000 mV/s were linear, as expected for a diffusion-limited electrochemical process for LSP electrochemical oxidation. Electron transfer coefficient α, diffusion coefficient D, and apparent reaction rate constant kf were 0. 77, 2. 47× 10^-5 cm^2/s and 3.46 × 10^-3 cm/s, respectively. The chang of the oxidation peak current with LSP concentration was examined by Square wave vohammetry （ SWV ）. The oxidation peak current of LSP versus its concentration showed a good linear relationship in a concentration range of 1.0 × 10^-6 ～ 5.6 ×10^-3 mol/L with a correlation coefficient of 0. 999 8 and a detection limit of 5.0 × 10^-7 mol/L by SWV response. The relative standard deviation was between 1.9% ～2.3%, and the recovery was in a range of 98% ～102%. The proposed method were applied to the determination of LSP in capsule samples with satisfied results.

关 键 词：赖诺谱利 碳糊电极 电化学性质 电分析方法 

分 类 号：O657.1[理学—分析化学] R917[理学—化学]