流动注射微乳液化学发光法测定溴丙胺太林  

Flow-injection Chemiluminescence Analysis of Propantheline Bromide in Microemulsion

作　　者：石文兵[1] 

机构地区：[1]长江师范学院化学系,重庆涪陵408003

出　　处：《应用化学》2008年第5期583-586,共4页Chinese Journal of Applied Chemistry

基　　金：重庆市教委资助项目(KJ061306);重庆市科技攻关计划项目;重庆市重点实验室开放基金资助项目

摘　　要：在酸性条件下，溴丙胺太林（PB）分子中N原子被质子化后与阴离子AuCl4^-形成离子缔合物．该缔合物被二氯甲烷带入鲁米诺的氯化十六烷基三甲基铵微乳液中，离解出来的AuCl4^-立即与鲁米诺产生化学发光。在一定浓度范围内，发光强度与溴丙胺太林的含量呈线性关系，从而间接测定溴丙胺太林的含量。在优化的试验条件下，线性范围为0．001～10×10^-6g／mL，检出限（3σ）为0．04×10^-9g／mL，对浓度为1×10^-6g／mL的溴丙胺太林进行11次平行测定，RSD为1．32％。Under acidic condition, the nitrogen atom in propantheline bromide was easily protonated and formed ion-complex with negative ion AuCl4^- The ion-complex was extacted with dichloromethane. When the ion-complex entered a reversed micellar microemulsion of cetyhrimethylammonium chlorine containing luminol, the dissociated AuCl4^- reacted with luminol, producing an analytical chemiluminescnece signal. Under the optimum conditions, the linear range is from 0. 001 to 10 × 10^-6 g/mL and the limit of detection is 0. 04 ×10^-9 g/mL with a relative standard deviation（n = 11 ） of ca. 1.32% for 1.0 × 10^-6 g/mL propantheline bromide. The method has been applied to the determination of the studied drug in tablets and biological fluids successfully.

关 键 词：微乳液 溴丙胺太林 化学发光 

分 类 号：O657.3[理学—分析化学] R917[理学—化学]