脂质体作为抗肿瘤药物载体的应用研究  

Application study of liposomes as carriers of anti-cancer drugs

作　　者：倪睿[1] 刘建平[1] 

机构地区：[1]中国药科大学药物制剂研究所,南京210009

出　　处：《药学服务与研究》2008年第2期89-92,共4页Pharmaceutical Care and Research

摘　　要：目前,应用脂质体作为抗肿瘤药物载体已成为趋势。脂质体可明显提高抗肿瘤药物的靶向性,延长药物的作用时间,降低药物毒性。作者对国内外普通脂质体和修饰脂质体(包括长循环脂质体、免疫脂质体、温度敏感脂质体和pH敏感脂质体)的相关文献进行了综述。结果表明,脂质体是抗肿瘤药物的理想载体,在肿瘤治疗中有着广阔的应用前景。At present, there is a tendency to use liposomes as carriers of anti-cancer drugs. Liposomes can enhance the targeting effect, prolong the blood circulation time of drugs and reduce the toxicity of encapsulated drugs. Domestic and foreign literature about common and modified liposomes （including long-circulating liposome, immunoliposome, temperature-sensitive liposome, pH-sensitive liposome） is reviewed. Liposome,which is an ideal carrier of anti-cancer drugs, has promising prospect in anti-cancer therapy.

关 键 词：脂质体 药物载体 抗肿瘤药 综述 

分 类 号：R943.5[医药卫生—药剂学]