短期胰岛素泵强化治疗对初诊2型糖尿病患者血清肿瘤坏死因子α、白细胞介素6水平的影响  

Effects of short-term insulin pump intensive treatment on tumor necrosis factor-or and interleukin-6 in new type 2 diabetic patients

作　　者：吕肖锋[1] 方堃[1] 

机构地区：[1]解放军北京军区总医院内分泌科,100700

出　　处：《中华全科医师杂志》2008年第5期338-339,共2页Chinese Journal of General Practitioners

摘　　要：比较63例初诊2型糖尿病患者胰岛素泵强化治疗前后血清肿瘤坏死因子α（TNF-α）、IL-6和胰岛素抵抗水平，治疗后TNF-α、IL-6水平及胰岛素抵抗均明显下降，差异均有统计学意义（P〈0．01）。说明短期胰岛素泵强化治疗可以显著改善血清TNF-α和IL-6的水平和胰岛素抵抗。Sixty three new type 2 diabetes （T2DM） mellitus were treated with insulin pump for 2 weeks. Free insulins, fasting plasma glucose, tumor necrosis factor-α （TNF-α） and interleukin （IL）-6 level and other parameters were measured before and after insulin treatment. HOMA-insulin resistance （HOMA-IR） and β-cell function （HOMA-β） were compared. After 2 weeks insulin intensive treatment, TNF-α and IL-6 level were significant lower （P 〈 0. 01 ）. HOMA-IR and HOMA-β were significant improved （P 〈0. 01 ）. TNF-α and IL-6 levels were positively associated with the body mess index and HOMA-IR （P〈0.01）. TNF-α, IL-6 and HOMA-IR could be significauly improved by short-term insulin pump intensive treatment in new T2DM patients with severe hyperglycemia.

关 键 词：肿瘤坏死因子Α 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌] R512.6[医药卫生—内科学]