百日咳、白喉、破伤风、乙型肝炎联合疫苗的实验研究  

Experimental Study on Acellular Pertussis VaccineDiphtheria toxoidTetanus toxoidRecombinant HBsAg Combined Vaccine

作　　者：孙述学[1] 乔瑞洁[1] 陈爱荣[1] 刘志源[1] 杨晓明[1] 何长民[1] 任魁[2] 李玉[2] 张昀[2] 孟秀园 郑菊梅[2] 

机构地区：[1]卫生部兰州生物制品研究所第三研究室 [2]卫生部兰州生物制品研究所疫苗三室

出　　处：《微生物学免疫学进展》1997年第4期21-24,共4页Progress In Microbiology and Immunology

摘　　要：对制备无细胞百日咳菌苗、白喉、破伤风、乙型肝炎联合疫苗的实验室条件进行了初步探索，实验结果表明，联合疫苗的配方以每毫升无细胞百日咳组分１５－１８μｇ．ＰＮ、白喉类毒素３０ｌｆ、破伤风类毒素７－１０ｌｆ和基因工程乙肝表面抗原２０μｇ为宜，稀释缓冲液选用０．８５％ＮａＣｌ溶液吸附效果较好，动物实验证明联合疫苗中各组分均安全有效。The experimental conditions of DTacPrHB combined vaccine were investigated,the results indicated that the formula Consisting of acellular pertussis vaccine 15-18ug.PN/ml,diphtheria toxoid 30lf/ml,tetanus toxoid 7-10lf/ml and recombined HBsAg 20ug/ml,using 0.85% Nacl as its solution is suitable for combination.Animal assay also showed the combined vaccine is safe and effective.

关 键 词：百日咳 白喉 破伤风 乙型肝炎 联合疫苗 

分 类 号：R510.3[医药卫生—内科学] R392－33[医药卫生—临床医学]