肺动脉高压大鼠模型的复制  

Pulmonic Hypertension Induced by Chronic Isobaric Hypoxia and Hypoxia with High Concentration of CO 2 in Rats

作　　者：杨晓静[1] 毛宝龄[1] 钱桂生[1] 赵自强[1] 

机构地区：[1]第三军医大学新桥医院呼吸内科研究所

出　　处：《上海实验动物科学》1997年第4期199-202,共4页Shanghai Laboratory Animal Science

摘　　要：采用直接吸入常压低氧（Ｏ２浓度为１０％）和低氧伴高二氧化碳（Ｏ２浓度为１０％，ＣＯ２浓度为６．５％）混合气体（每天８ｈ，共４周）的方法制备肺动脉高压大鼠模型。观察实验大鼠的平均肺动脉压、平均右心室压、右心室重量及心脏和肺脏的病理学改变，并作血气分析。结果表明。Pulmonic hypertension in 2 groups of Wistar rats was induced by exposing the rats to an isobaric atmosphere containing 10% O 2, and the other containing 10% O 2 with 6.5% CO 2 respectively for 8h daily for 4 weeks. The mean pulmonary arterial pressure and right ventricular pressure, right ventricular weight, blood gas analysis and pathological changs of the hearts and lungs in the rats were observed. The results showed that the pulmonic hypertension models could be established in a short time (4 weeks),and could mimic cor pulmonale with respiratory failure in human better than that induced by hypobaric hypoxia.

关 键 词：肺动脉高压 大鼠 动物模型 复制 

分 类 号：R543.2[医药卫生—心血管疾病]