血红素加氧酶系统及其在哮喘的作用  

Heme Oxygenase System and its Role Played in Asthma

作　　者：徐璇[1] 杨作成[2] 李云[1] 钟礼立[1] 

机构地区：[1]湖南省人民医院儿科,长沙410002 [2]中南大学湘雅三医院儿科,长沙410013

出　　处：《医学综述》2008年第10期1501-1503,共3页Medical Recapitulate

摘　　要：血红素加氧酶(HO)是组成微粒体酶系统的重要组分之一,它能催化降解血红素生成胆红素、游离铁离子和一氧化碳(CO)。HO有3种同工酶,其中HO-1除了促进血红素代谢的作用外,还具有抗炎、抗凋亡、抗增生和抗氧化应激等许多重要生物学作用。HO-1及其代谢产物作用的研究将为哮喘的临床治疗开辟新的途径。Heme oxygenase（HO） is one of the important component of microsomal enzyme system, which can catalyze degradation of haemoglobin into bilirubin,ferri ion, and carbon monoxide. HO has three kinds ofisozyme,one of them is HO-1 ,which alao has many important biological effects besides its role in promoting the haemoglobin metabolism, such as anti-inflammatory, anti-apoptosis, anti-proliferation, anti-oxidative stress and so on. The study about HO-1 and its metabolic products will explore new pathway for the clnical therapy for asthma.

关 键 词：血红素加氧酶系统 一氧化碳 哮喘 抗炎作用 

分 类 号：R562.25[医药卫生—呼吸系统]