阿伐他汀对去势大鼠骨折愈合的影响  

Study on Atorvastatin' s effects on fracture union of emasculated rats

作　　者：王慧[1] 王大风[1] 

机构地区：[1]温州市第三人民医院,325000

出　　处：《浙江临床医学》2008年第5期582-584,共3页Zhejiang Clinical Medical Journal

摘　　要：目的研究阿伐他汀局部注射对去势大鼠骨折愈合的影响。方法2月龄雌性SD大鼠采用去势方法模拟人绝经后骨质疏松症,进一步建立胫骨骨折髓内钉内固定模型,实验组于骨折端皮下注射阿伐他汀(10mg.kg-1.d-1×5d),对照组注射无阿伐他汀的溶剂。骨折后1、2、4周取标本,通过X线片、生物力学、组织病理学以及组织形态计量学等评价两组骨折愈合质量。结果与对照组相比,实验组骨痂横截面积在骨折后1周、2周分别增加24.3%(p<0.05)和33.2%(p<0.05);骨痂最大载荷在骨折后2周、4周分别增加43.1%(p<0.05)和69.8%(p<0.05);组织学显示实验组新生编织骨较对照组多且排列致密。结论局部应用阿伐他汀可促进去势大鼠骨折愈合。Objective To explore the influence of Atorvastatin on fracture union of emasculated rats. Methods Postmenopausal osteoporosis was simulated on emasculated female rats of 2 months old , further model of internal fixation with bone nail in treating tibia fracture was developed . In treating group , Atorvastatin was subcutaneous injected （10mg·kg^-1·day^-1×5day） locally at fracture site , in control group , solution without Atorvastatin was used as control .Spacemen were collected 1,2,4 weeks after fracture , the quality of fracture union was evaluated by X-ray ,vitedynamics,histopathology and morphometry. Results The section area of osteotylus in the treating group inereased 24.3% （p〈0.05） and33.2% （p〈0.05） in one and two weeks after fracture; maximal load of osteotylus increased 43.1% （p〈0.05） and 69.8 % （p〈0.05） two and four weeks after fracture ; histological finding showed neogenesis woven bones were more and compactly arranged in treating group than those in control one . Conclusions Local Atorvastatin injection helps the fracture union in fracture union of emasculated rats.

关 键 词：阿伐他汀 大鼠 骨质疏松 骨折愈合 

分 类 号：R96[医药卫生—药理学]