142例新生儿溶血病血清学检测结果分析  

Analysis of Serological Test Results of 142 Cases of Hemolytic Disease of Newborn

作　　者：罗洪清 元霞 郑静敏 

机构地区：[1]韶关市中心血站,韶关512026

出　　处：《中国生物制品学杂志》2008年第5期428-429,共2页Chinese Journal of Biologicals

摘　　要：目的对本地区142名新生儿溶血病患者进行血清学检测，评价直接抗人球蛋白试验、游离抗体试验和抗体释放试验在该病诊断中的价值。方法对2005年1月-2007年6月各医院送检的高胆红素血症新生儿血液标本进行“三项试验”。结果142名新生儿溶血病患者中，血型分布规律为：B〉A〉AB〉0，54．22％为B型，43．66％为A型，二者差异有显著意义。直抗试验阳性率为76．76％，释放试验阳性率为100％，游离试验阳性率为50．70％。释放试验阳性的A型患者中，抗-AB检出率为47．17％，B型患者中的检出率为53．03％，二者差异无显著意义。结论释放试验敏感度最高，是判定新生儿溶血病最有力的证据，在本地区，B型新生儿可能更易患新生儿溶血病。Objective To analyze the serology of 142 cases of hemolytic disease of newborn （HDN） in Shaoguan Prefecture, Guangdang Province, China, and evaluate the significance of direct anfiglobulin test, free antibody test and antibody release test in diagnosis of HDN. Methods Perform the above-mentioned three tests on the blood specimens of newhorm with hyperbilirubinaemia collected from January 2005 toJune2（g）7,Resnlts ThedistribufionsofA, B, AB and O blood groups in the 142casesofHDNwere43.66%,54.22%,1.41% and 0.70% respectively, and those of A and B blood groups showed significant difference. The positive rates in direct antiglobulin test, free antibody test and antibody release test were 76.76% ,50.70% and 100% respectively.The anti-AB positive rates in patients of A and B blood groups were 47 % and 53 % respectively, which showed no significant difference. Conclusion Of the above-mentioned three tests, andtibody release test was of the highest sensitivity and provided the most reliable basis for the diagnosis of HDN. In Shaoguan Prefecture, the newborns of B blood group might be more susceptible to HDN.

关 键 词：新生儿溶血病 血清学检测 直接抗人球蛋白试验 游离抗体试验 抗体释放试验 

分 类 号：R722.18[医药卫生—儿科]