卡维地洛对充血性心力衰竭患者心肌肌钙蛋白I及心功能的影响  

The effects of carvedilol on cardiac troponin I and cardiac function in patients with congestive heart failure

作　　者：易远明[1] 

机构地区：[1]广东省吴川市人民医院心内科,广东吴川524500

出　　处：《吉林医学》2008年第9期719-721,共3页Jilin Medical Journal

摘　　要：目的:观察卡维地洛对充血性心力衰竭(CHF)患者心肌肌钙蛋白I(cTnI)及心功能的影响。方法:将42例CHF患者随机分为对照组和实验组,两组疗程均为2周。观察治疗前后cTnI以及左室射血分数、左室短轴缩短率、每搏出量、心输出量及心脏指数等指标变化情况。结果:经治疗2周后,实验组总有效率显著高于对照组,两组比较差异有统计学意义(P<0.05);治疗后两组患者cTnI较治疗前显著降低,实验组优于对照组(P<0.05或P<0.01)。结论:CHF患者存在cTnI异常,卡维地洛可纠正CHF患者异常的cTnI水平,改善心功能。Objective To observe the effects of carvedilol on cardiac troponin I （cTnI）and cardiac function in patients with congestive heart failure （CHF）. Method Forty - two CHF patients were randomly divided into carvedilol group （ n = 21 ） and control group （ n = 21 ）. Patients in control group were treated with regular cardiac medicine. Patients in carvedilol group were given an administration of carvedilol on the basic of regular cardiac medicine therapy for 2 weeks. Before and 2 weeks after treatment, the plasma levels of cTnI, LVEF, FS, SV, CO and CI were determined. Results The total effective rate was higher in carvedilol group than that in control group （ P 〈 0.05 ） ; the plasma levels of cTnI decreased significantly in both group 2 weeks after treatment, but cTnI was lower in carvedilol group than that in control group （P 〈0.05 or P 〈 0.01 ）. Conclusion Carvedilol can improve heart function and rectify abnormal cardiac troponinI.

关 键 词：卡维地洛 充血性心力衰竭 心肌肌钙蛋白I 心功能 

分 类 号：R541.6[医药卫生—心血管疾病]