子痫前期患者血清及胎盘促肾上腺皮质激素释放激素水平的变化及意义  

The changes and significance of serum and placental corticotropin releasing hormone(CRH) in preeclampsia

作　　者：史骁梁[1] 符孜牧[1] 王浛知[2] 董昱岳[2] 

机构地区：[1]浙江省绍兴市妇幼保健院,310006 [2]浙江大学医学院附属妇产科医院

出　　处：《中国妇幼保健》2008年第15期2078-2080,共3页Maternal and Child Health Care of China

摘　　要：目的:了解子痫前期患者血清和胎盘组织促肾上腺皮质激素释放激素(CRH)的变化及其意义。方法:采用ELISA测定36例子痫前期患者(子痫前期组)和39例正常孕妇(对照组)血清和胎盘血清CRH浓度组织蛋白提取液中CRH浓度,并进行组间比较。结果:子痫前期患者血清CRH浓度为(5.661±2.895 0)pmol/L,与正常妊娠时血清CRH浓度(8.753 9±2.741 0)pmol/L比较呈显著下降(P<0.001),子痫前期患者胎盘组织中CRH相对浓度为(0.314 8±0.083 65)pmol/g蛋白与正常妊娠时(0.317 8±0.110 0)pmol/g蛋白比较则没有显著性差异(P>0.05)。结论:子痫前期患者血清CRH显著降低,是子痫前期的一个重要病理生理变化,可能与疾病的的发生、发展有关。Objective： To understand the changes and significance of eortieotropin releasing hormone in patients with preeclampsis. Methods： CRH in serum and placental homogenate from 36 preeelamptie （PE） and 39 normal pregnancies were determined by means of ELISA and comparison was done between groups. Results： In PE group, the concentrations of CRH in maternal serum （5.661 ±2. 895 0 pmol/L） was obviously lower than that in control group （8. 753 9 ±2. 741 0 pmol/L）, but no difference in placentas between the two groups [ （0. 314 8 ±0. 083 65 ） pmol/g, （0. 317 8 ± 0. 110 0） pmol/g, respectively] . Conclusion： The low level of CRH in maternal serum is an important pathological change in preeelampsia, and may play a role in the progress of the disease.

关 键 词：子痫前期 促肾上腺皮质激素释放激素 胎盘 血清 

分 类 号：R714.245[医药卫生—妇产科学]