米非司酮药流时LIF、ICAM-1在绒毛组织中的表达及意义  

The expression of LIF and ICAM-1 in chorionic villi during mifepristone-induced abortion

作　　者：王健[1] 宋月轻[1] 秦姗[1] 闫晓娟[1] 

机构地区：[1]河北医科大学第三医院妇产科,河北石家庄050051

出　　处：《中国妇幼保健》2008年第15期2129-2131,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨米非司酮对早孕绒毛组织中白血病抑制因子(LIF)、细胞间粘附分子-1(ICAM-1)表达的影响。方法:采用免疫组化染色测定绒毛组织中LIF和ICAM-1的表达,其中正常早孕人工流产组20例,米非司酮药物流产组22例。结果:LIF在正常早孕绒毛组织中的阳性表达率为85%(17/20),在米非司酮药物流产组阳性表达率为50%(11/22);正常早孕绒毛组织中ICAI-1阳性表达率为80%(16/20),米非司酮药物流产绒毛组织中阳性表达率为45%(10/22),差异均有显著性(P<0.05)。结论:LIF和ICAM-1与胚胎着床及维持正常早孕有关。米非司酮可引起人早孕绒毛组织中LIF和ICAM-1的表达降低,可能是抗早孕终止妊娠机理之一。Objective： To investigate the effects of mifepristone on the expression of leukemia inhibitory fator （LIF） and intercellular adhesion molecule - 1 （ ICAM - 1 ） in chorionic villi of early pregnancy. Methods： The expression of LIF and ICAM - 1 in chorion villi of normal early pregnancy （20 cases ） and mifeprisone - induced abortion （22 cases ） were tested by technique. Results： There were significant differences in the expression of both LIF （50%, 85% ） and ICAM - 1 （45%, 80% ） in mlfe- prisone - induced abortion and normal early pregnancy （ P 〈 0. 05 ） . Conclusion： LIF and ICAM - 1 may be associated with embryo im- plantation and early pregnancy maintenance. One of the mechanisms of mffepristone - induced abortion may be via the reduction of LIF and ICAM - 1 expression in chorionoc villi of early pregnanacy.

关 键 词：米非司酮 绒毛 白血病抑制因子 细胞间粘附分子-1 

分 类 号：R715[医药卫生—妇产科学]