Pd/C催化去甲基金霉素制备6-去甲基-6-脱氧四环素  

Synthesis of 6-Demethyl-6-deoxytetracycline by Pd/C Catalytic Hydrogenation of Demeclocycline

作　　者：陈德福[1] 达世俊[1] 李瀛[1] 

机构地区：[1]兰州大学功能有机分子化学国家重点实验室

出　　处：《中国医药工业杂志》2008年第5期325-327,共3页Chinese Journal of Pharmaceuticals

摘　　要：去甲基金霉素的7-位氯和6-位羟基,在Pd/C催化下于4～8MPa压力下经两步氢化分别脱去,生成广谱抗菌剂米诺环素的重要中间体6-去甲基-6-脱氧四环素,总收率约为56%。6-Demethyl-6-deoxytetracycline, the key intermediate of minocycline was obtained facilely by twostep catalytic hydrogenation of demeclocycline under 4 - 8MPa pressure in the catalysis of Pd/C with an overall yield of about 56%.

关 键 词：6-去甲基-6-脱氧四环素 去甲基金霉素 催化氢化 抗生素 中间体 合成 

分 类 号：R978.14[医药卫生—药品] O624[医药卫生—药学]