5-氟胞苷和5＇-脱氧-5-氟胞苷的合成  

Synthesis of 5-Fluorocytidine and 5'-Deoxy-5-fluorocytidine

作　　者：方峰[1] 万欢[1] 许煦[2] 马红梅[1] 冀亚飞[1] 

机构地区：[1]华东理工大学药学院 [2]华东理工大学化工学院,上海200237

出　　处：《中国医药工业杂志》2008年第5期328-329,343,共3页Chinese Journal of Pharmaceuticals

摘　　要：5-氟胞嘧啶经苯甲酰化保护后分别与供糖体四乙酰核糖和5-脱氧三乙酰核糖缩合,再经氨解,以45.7%和42.6%的收率分别制得5-氟胞苷和5'-脱氧-5-氟胞苷。5-Fluorocytidine and 5＇-deoxy-5-fluorocytidine were prepared by condensation of pre-benzoylated 5-fluorocytosine with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose or 5-deoxy-l,2,3-tri-O-acetyl-β-D-ribofuranose, followed by aminolysis in overall yields of 45.7 % and 42.6 %, respectively.

关 键 词：5-氟胞苷 5'-脱氧-5-氟胞苷 苯甲酰化 卡培他滨 中间体 合成 

分 类 号：O629.13[理学—有机化学]