6-甲氧基-1,2,3,9-四氢-4H-咔唑-4-酮的合成  

Synthesis of 6-Methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one

作　　者：盛韦[1] 郑优丽 张奇虹[1] 仇缀百[1] 

机构地区：[1]复旦大学药学院药物化学教研室,上海200032

出　　处：《中国医药工业杂志》2008年第5期330-331,共2页Chinese Journal of Pharmaceuticals

摘　　要：4-甲氧基苯肼盐酸盐和1,3-环己二酮在乙酸催化下缩合得到3-[(4-甲氧基苯基)亚肼基]环己-1-烯醇盐酸盐,然后在二苯醚中经Fischer反应闭环生成6-甲氧基-1,2,3,9-四氢-4H-咔唑-4-酮,总收率约为57%。6-Methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one was synthesized from 4-methoxyphenylhydrazine hydrochloride and 1,3-cyclohexanedione by acetic acid catalyzed condensation to give 3- E（4-methoxyphenyl）hydrazono] cyclohex- 1-enol hydrochloride, followed by Fischer reaction with an overall yield of about 57%.

关 键 词：6-甲氧基-1 2 3 9-四氢-4H-咔唑-4-酮 中间体 合成 

分 类 号：O626[理学—有机化学]