康莱特胶丸联合TACE治疗中晚期原发性肝细胞癌的疗效观察  

Effects of kanglaite capsules combined with transcatheter arterial chemoembolization on patients with advanced unresectable hepatocellular carcinoma

作　　者：李道俊[1] 许新华[2] 彭绪申[2] 薛峰[2] 戴德兰[2] 文彩虹[3] 

机构地区：[1]三峡大学第一临床医学院肿瘤科,宜昌443003 [2]宜昌市中心人民医院肿瘤科,宜昌443003 [3]三峡大学肿瘤研究所临床部,宜昌443003

出　　处：《肿瘤》2008年第5期436-439,共4页Tumor

摘　　要：目的:观察康莱特胶丸联合肝动脉化学栓塞(transcatheter arterial chemoembolization,TACE)治疗中晚期原发性肝癌的疗效。方法:将65例患者随机分为2组,综合组(康莱特胶丸+TACE)32例,对照组(单纯TACE)33例,比较2组近期疗效、血清甲胎蛋白(alpha fetoprotein,AFP)、外周血T淋巴细胞亚群(T lymphocyte subsets,T-LS)、生活质量(quality of life,QOL)、肿瘤进展时间(time to progession,TTP)和不良反应。结果:综合组客观有效率、血清AFP与对照组相仿(P>0.05),T-LS(CD3+、CD4+、CD4+/CD8+细胞比值)、QOL、TTP、肝脏不良反应等方面明显优于对照组,差异有统计学意义(P<0.05)。结论:康莱特胶丸联合TACE是治疗失去手术治疗机会的原发性肝癌的有效方法之一。Objective： To observe the clinical effects of kanglaite capsules combined with transcatheter arterial chemoembolization （TACE） on patients with advanced unresectable hepatocellular carcinoma （HCC）. Methods： Sixty-five cases were divided into 2 groups at random. In treatment group, 32 patients received kanglaite capsules after TACE and 33 patients in control group were treated with TACE singly. The objective response rate （ RR ）, serum alpha fetoprotein （ AFP）, peripheral blood T lymphocyte subsets （T-KS）, quality of life （QOL） , time to progression （TIP）, and adverse reaction were observed. Results： The objective response rate and serum alpha fetoprotein levels had no significant difference between the two groups （P 〉0.05 ）. Treatment group was superior to control group in the quality of life （QOL）, the time to progression （ITP）, peripheral blood T lymphocyte subsets （CD3^＋ , CD4^＋ , CD4^＋/CD8^＋ ratio）, and frequency of adverse reactions in liver. The difference was significant （P 〈 0.05 ）. Conclusion： Kanglaite capsules combined with TACE was an effective method for primary HCC patients who have lost the surgical chance.

关 键 词：肝肿瘤 药物疗法 化学栓塞 治疗性 康莱特胶丸 

分 类 号：R735.7[医药卫生—肿瘤] R730.53[医药卫生—临床医学]