绞股兰皂甙对庆大霉素所致大鼠急性肾功衰的保护作用  

Gypenosides' Protective Effect on Acute Renal Failure Induced by Gentamycin in Rats

作　　者：刘惠[1] 段永寿[1] 白云凯[1] 肖桦[1] 普苹[1] 黄洁[1] 阮敬华[1] 

机构地区：[1]昆明医学院第一附属医院

出　　处：《昆明医学院学报》1997年第4期4-6,共3页Journal of Kunming Medical College

摘　　要：为研究绞股兰皂甙对庆大霉素所致的急性肾功能衰竭的保护作用，用Ｗｉｓｔａｒ大鼠３０只随机分为３组：庆大霉素组、绞股兰皂甙保护组和正常对照组，每组１０只观察肾功能和形态学变化，同时测定血清超氧化物歧化酶和血清丙二醛含量结果显示：绞股兰皂甙保护组血清ＢＵＮ，Ｃｒ和Ｕｒ较庆大霉素组明显改善。To study the protective effect of gypenosides (GPS) on acute renal failure (ARF) induced by Gentamycin (GM), 30 Wistar rats were divided randomly into three groups: GM, GPS and normal control, each consisting of 10 rats. Observation was made on the renal function and morphylogical change at the same time the serum superoxide (SOD) and malondialdehyde (MDA) were measured (MDA) were measured. The results showed that the serum BUN, Cr and Ur were markedly improved more and the pathomorphylogy change of renal tissue was obviously alleviated more in GPS protective group than in GM group. This suggested that GPS has a remarkably protective effect on GM-induced ARF.

关 键 词：急性 肾功能衰竭 绞股兰皂甙 庆大霉素 

分 类 号：R692.5[医药卫生—泌尿科学]