美托洛尔注射液在急性心肌梗死中的应用  

Therapeutic Effect of Intravenous Metoprolol on Patients with Acute Myocardial Infarction

作　　者：熊汗莲 李瑞荣[2] 李林锋[3] 

机构地区：[1]新建县人民医院内科 [2]中国人民解放军91551部队卫生处 [3]江西省人民医院心内二科

出　　处：《实用临床医学（江西）》2008年第4期30-31,35,共3页Practical Clinical Medicine

摘　　要：目的观察美托洛尔注射液在急性心肌梗死治疗中的安全性和有效性。方法选择急性心肌梗死患者80例,随机分为治疗组与对照组,治疗组应用美托洛尔注射液,继之口服美托洛尔。对照组不使用美托洛尔等β受体阻滞剂,常规治疗两组相同。结果治疗组与对照组比较,病情更加稳定,再发胸痛次数明显减少,两者有显著差异(P<0.05),恶性心律失常发生率明显降低(P<0.01),急性左心衰竭发生率及病死率明显降低(P<0.05)。结论早期应用美托洛尔注射液对AMI患者能有效降低心律失常事件、心肌缺血事件及猝死率,是安全有效的,值得临床推广。Objective To observe the therapeutic effect and safety of intravenous metopmlol on patients with acute myocardial infarction. Methods Eighty patients were divided into metopmlol group and control group randomly. Patients in metoprolol group were injected metoprolol intravenously at doses of 5 - 15 mg and then treated with oral metoprolol. Patients in control group were treated with basic medical therapy without metoprolol. Results Compared with control group, chest pain in metoprolol group was reduced（P〈0.05）the malignant arrhythmia were decreased markedly（P〈0.01）. The fatality rate in metoprolol group were decreased markedly（P〈0.05）. Conclusion It is effective and safe that administering intravenous metoprolol as early as possible to patients with acute myocardial infarction. It is worth generalizing the treatment into clinic.

关 键 词：急性心肌梗死 美托洛尔 疗效 安全性 

分 类 号：R542.22[医药卫生—心血管疾病]