24小时动态血压及多普勒超声心动图仪监测下的缬沙坦对轻中度高血压患者疗效及左室肥厚的影响  

The effect of Valsartan on Hypertension and Hypertrophy of left ventricle

作　　者：刘淼[1] 高敬[1] 华琦[1] 

机构地区：[1]首都医科大学宣武医院心内科,北京100053

出　　处：《临床和实验医学杂志》2008年第5期17-18,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨缬沙坦治疗轻中度原发性高血压病疗效及对左室肥厚的逆转作用。方法门诊确诊40例轻中度高血压病患者在停服各种心血管活性药物2周后服用缬沙坦(80mg/d)4周。所有患者在用药前及治疗后4周末复查动态血压及心脏超声。结果4周末24h收缩压、舒张压,白昼及夜间收缩压、舒张压,收缩压及舒张压负荷均显著降低(P<0.05)。左室质量指数较治疗前降低(P<0.05)。结论缬沙坦对轻中度高血压病患者有明显降压效果。并且可在短期内逆转左室肥厚。Objective To study the effect of Valsartan on Hypertension and Hypertrophy of left ventricle. Methods 40 patients with mild or moderate essential hypertension were received Valsartan 80 mg/d for 4 weeks. Ambulatory blood pressure monitoring and echocardiography were measured before and after treatment. Results The blood pressure decreased at fourth week. And LVMI was also decreased in patients with essential hypertension. Conclusion Valsartan is an effective drug to treat mild or moderate essential hypertension. And hypertrophy of left ventricle can be improved with Valsartan in short term.

关 键 词：原发性高血压 缬沙坦 左心室 肥大性 

分 类 号：R541.3[医药卫生—心血管疾病]