重庆市区健康成人胰岛素样生长因子-1血清浓度测定  

Determination of the adult serum level of the insulin-like growth factor-1 in Chongqing urban field

作　　者：张华[1] 倪卫东[1] 陆慧[1] 张弓[1] 

机构地区：[1]重庆医科大学附属第一医院骨科,重庆400016

出　　处：《中国骨质疏松杂志》2008年第5期346-348,共3页Chinese Journal of Osteoporosis

摘　　要：目的了解重庆市区健康成人不同年龄段和不同性别间胰岛素样生长因子-1（insulin-like growth factor-1，IGF-1）血清浓度水平，为研究疾病状态下人体血清1GF-1的浓度变化提供有益的参考数据。方法随机选取重庆市区90名健康成人血清标本，其中青年组（18～45岁），中年组（46～60岁），老年组（〉60岁）各30例，采用ELISA方法测定IGF-1浓度，将所测值在各年龄组、性别组之间行统计学比较。结果90名健康成人血清IGF-1的浓度平均值为（159．85±77．84）ng·ml^-1；老年组浓度显著低于青、中年组；老年女性组浓度显著低于青、中年女性组；余不同年龄、性别之间未见统计学差异。结论重庆市区老年人，尤其是老年女性，IGF-1血清浓度显著降低。Objective To evaluate possible differences in the serum levels of Insulin-like growth factor-1 （IGF-1） for healthy adults of different ages and sexes in Chongqing urban field, providing the useful reference for the varieties of the serum IGF-1 level in the ill-condition. Methods Ninty healthy people in Chongqing urban region were selected randomly and all enrolled were divided into the young group（ 18-45 y）, the middle-aged group （46-60 y） and the old group（ 〉 60 y）, each group 30 people. Blood from the 90 people were collected and followed by measurement of the serum concentration of IGF-1 with Enzyme-linked immunosorbent assay, statistical analysis was then performed to see whether differences exit in values among groups. Results The mean serum level of the IGF- 1 for the 90 healthyhuman subjects was （159.85 ± 77.84） ng/ml;the concentration of the IGF-1 for the old-aged group was significantly lower than those for the youth and the middle-aged groups, especially for the female（both P 〈 0.05）, there were no significant differences amnog other different aged-groups and sexual-groups. Conclusion The serum level of the IGF-1 for the old-aged people in Chongqing urban region is significantly lower than the youth and the middle-aged, especially for the female.

关 键 词：胰岛素样生长因子-1 健康成人 血清浓度 重庆 

分 类 号：R33[医药卫生—人体生理学]