Lag-3基因rs870849多态性和CD_4基因rs2515733多态性与ITP易感性之间的联系  

Association between LAG-3 gene rs870849 and CD4 gene rs2515733 polymorphisms with susceptibility of idiopathic thrombocytopenic purpura

作　　者：刘爱娟[1] 许剑辉[1] 陈晓梨[1] 陈振萍[1] 葛菁[1] 王晓燕[1] 杨仁池[1] 

机构地区：[1]中国医学科学院北京协和医学院血液学研究所血液病医院,天津300020

出　　处：《山东医药》2008年第13期20-22,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30670900)。

摘　　要：目的分析CD4基因rs2515733多态性和Lag-3基因rs870849多态性与特发性血小板减少性紫癜(ITP)易感性之间的关系。方法采用聚合酶链反应—限制性片段长度多态性方法(PCR-RFLP)分析157例ITP患者和136例正常人的基因分型。结果CD4基因rs2515733多态性位点基因频率和Lag-3基因rs870849多态性位点基因频率在患者组与对照组之间无显著差异。结论ITP患者和正常人CD4基因rs2515733多态性和Lag-3基因rs870849多态性基因频率的分布类似,这两个基因的多态性与ITP易感性无关。Objective To investigate the relations between the CD4 gene rs2515733 polymorphism and LAG-3 gene rs870849 polymorphism and the susceptibility of idiopathic thromboeytopenie purpura（ITP）. Methods Genotyping of CD4 gene rs2515733 and LAG-3 gene rs870849 in 191 patients with ITP and 136 healthy individuals were analyzed by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results There was no statistical difference in gene frequency of CD4 gene rs2515733 and LAG-3 gene rs870849 polymorphism site between ITP group and the control group. Condusions There is the similar gene frequency distribution of CD4 gene rs2515733 and Lag-3 gene rs870849 pol- ymorphism between ITP patients and healthy volunteers, the CD4 gene rs2515733 and Lag-3 gene rs870849 polymorphism have no relation with ITP susceptibility.

关 键 词：紫癜 血小板减少性 特发性 多态性 CD4基因 lag-3基因 自身免疫疾病 

分 类 号：R558[医药卫生—血液循环系统疾病]