射频消融对血小板活性的影响  

Effects of radiofrequency catheter ablation on platelet aggregability

作　　者：曾秋棠[1] 张彦周[1] 于世龙[1] 陈志坚[1] 张家明[1] 

机构地区：[1]同济医科大学心血管病学研究所,武汉430022

出　　处：《临床心血管病杂志》1997年第5期259-261,共3页Journal of Clinical Cardiology

摘　　要：为探讨射频消融（RFCA）术后外周血管栓塞发生机理，以28例室上性心动过速为对象，在术前、术后即刻分别采股动脉、静脉血标本观察血小板半峰值聚集时间（T1／2），最大聚集率（Ma％）及血小板膜糖蛋白Ⅳ（GPⅣ），凝血酶敏感蛋白（TSP）的变化。结果表明消融术后即刻与术前比较：ADP和胶原诱导的股静、动脉血小板T1／2均缩短；ADP和胶原血小板Ma％均明显增高；静急状态下血小板膜上GPⅣ、TSP分子数无统计学差异；凝血酶诱导后血小板膜GPⅣ明显增高和TSP数量明显增多。术前、术后股动脉与股静脉标本之间上述各项指标均无差异。提示RFCA可引起血小板活性增高，且为全身系统性改变，它在一定程度上增加了外周血管栓塞的危险性。For studying the mechanism of systemic thromboembolism in patients after receiving radiofrequency catheter ablation (RFCA), the changes of the time of half maximum aggregation (T1/2 ) of platelet, the maximunl aggregation (Ma ) of platelet, platelet membrane GPIV and thrombospondin(TSP) of the blood samples which drawn from femoral arteries,femoral veins of 28 patients with supraventricular tachycardia (SVT)before and immediately after RFCA were observed. The results showed: T 1/2 induced by ADP and collagen after RFCA were significantly shorter than that before RFCA; Ma induced by ADP and collagen were apparently higher than that before RFCA; there was no statistical difference in resting platelet membrane GPIV and TSP in molecular amount between be fore and after RFCA. The platelet membrane GPIV and TSP activated by thrombin after RFCA were markedly higher than that before RFCA. There were no difference in every item mentioned above between samples obtained from femoral ariteries and from femoral veins after RFCA respectively. It indicated that the evolution of platelet aggregability caused by RFCA might be a systemic change, which enhanced the occurrence of systemic thromboembolism.

关 键 词：血小板聚集 射频消融术 心律失常 血管栓塞 

分 类 号：R541.705[医药卫生—心血管疾病] R543.02[医药卫生—内科学]