血清乳胶凝集试验诊断肺隐球菌病的临床对照研究  

The diagnostic value of serum latex agglutination test for pulmonary cryptococcosis

作　　者：牟向东[1] 李若瑜[2] 万喆[2] 王广发[1] 柳平[3] 王仁贵[4] 何冰[1] 

机构地区：[1]北京大学第一医院呼吸内科,100034 [2]北京大学第一医院皮肤性病科、真菌和真菌病研究中心,100034 [3]北京大学第一医院病理科,100034 [4]北京大学第一医院影像科,100034

出　　处：《中华结核和呼吸杂志》2008年第5期360-363,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的评价乳胶凝集试验检测血清隐球菌荚膜多糖抗原对肺隐球菌病的临床诊断价值。方法选择2000年7月至2007年7月北京大学第一医院收治的、疑诊为肺部隐球菌感染患者27例，均行血清乳胶凝集试验和肺活检组织病理检查。结果经病理证实的肺隐球菌病9例，乳胶凝集试验均阳性；非隐球菌感染患者18例，乳胶凝集试验均阴性。乳胶凝集试验的敏感度和特异度均为100％。结论血清乳胶凝集试验对肺隐球菌病具有很高的诊断价值。Objective To evaluate the diagnostic value of serum cryptococcal capsular polysaccharide antigen latex agglutination test （LA） for pulmonary cryptococcosis. Methods Serum and lung biopsy specimens of 27 patients, who were suspected of having pulmonary cryptococcosis based on clinical presentations and imaging features, were collected from July 2000 to July 2007 in the First Hospital of Peking University. LA test and histopathological examination were performed in all the patients. Results Histopathological examination confirmed pulmonary cryptococcosis in 9 cases, all of whom were positive for serum LA test. The other 18 cases were confirmed to have no cryptococcosis and all of them were negative for serum LA test. Therefore, the sensitivity and specificity of LA test were both 100%. Conclusion The diagnostic value of serum LA test for pulmonary Cryptococcosis is high.

关 键 词：隐球菌病 乳胶结合试验 隐球菌荚膜抗原 

分 类 号：R686[医药卫生—骨科学]