分子印迹液相色谱整体柱  

Monolithic Column of Molecularly Imprinted Polymers for Liquid Chromatography

作　　者：李振莹[1] 段宏泉[1] 黄艳萍[1] 刘照胜[1] 

机构地区：[1]天津医科大学药学院,天津300070

出　　处：《化学进展》2008年第5期747-753,共7页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20575045);天津市教委科研基金项目(No.20050117)资助

摘　　要：分子印迹是合成分子识别材料的新兴技术,整体柱是新型的色谱固定相技术。将分子印迹聚合物与整体柱技术相结合,可以有效提高液相色谱的分离效率,有助于推动整个分离科学的发展,意义重大,是当今分析化学的研究热点。本文就分子印迹液相色谱整体柱的制备合成、色谱分离条件以及物理化学特性评价方法等方面的研究进展进行了较系统的综述,并对该技术目前存在的问题和发展前景进行了探讨。Molecular imprinting is a new approach to prepare predictable selectivity phase stationary and monolithic column is a novel technology for chromatographic stationary phase. The combination of monolith and molecularly imprinted polymers （MIPs） integrates the high efficiency of liquid chromatography and the high selectivity of MIPs, which will accelerate the develpoment of MIPs technique in the field of separation science. Therefore, the research in this field has attracted considerable interests and plays an important role in the area of analytical chemistry. In this review, the progress of molecularly imprinted monolith is summarized in detail from the polymerization conditions to prepare MIPs monolith, the separation conditions to evaluate the efficiency of MIPs, and the method of characterizing MIPs＇ physical and chemical properties concerning the application of liquid chromatography-based MIPs. The limitations and prospective applications of the technique related with MIPs monolithic column are also discussed.

关 键 词：分子印迹 整体柱 液相色谱 原位聚合 

分 类 号：O657.72[理学—分析化学]