超滤膜技术分离杜仲叶绿原酸的研究  

Study on Isolation of Chlorogenic Acid from Eucommia ulmoides Leaves by Ultrafiltration Technique

作　　者：杨祖金[1] 江燕斌[2] 葛发欢[1] 袁雨婕[1] 余少冲[1] 

机构地区：[1]中药提取分离过程现代化国家工程研究中心,广东广州510240 [2]华南理工大学化工与能源学院,广东广州510640

出　　处：《中药材》2008年第4期585-588,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:研究超滤膜技术应用于杜仲叶绿原酸的分离纯化。方法:以绿原酸转移率为指标,考察料液温度、超滤压力、超滤时间、膜截留分子量对绿原酸转移率的影响。结果:膜截留分子量200000,超滤温度40℃、超滤压力0.36MPa、超滤时间20min、加水量24L时,绿原酸转移率为99.38%。结论:超滤膜技术分离纯化杜仲叶绿原酸效果较好,可应用于产业化。Objective：To isolate and purify Chlorogenic acid from Eucommia ulmoides leaves by uhrafiltration technique. Methods： Chlorogenic acid transferring ratio was investigated by temperature, pressure, time, cut-off molecular mass. Results ：The optimal conditions for the uhrafiltration technique were finally determined. It was found that, for the membrane with a cut-off molecular mass of 20000, when the temperature, pressure, time were respectively 40℃, 0. 36 MPa , 20 minutes and adding 24L water, yield of Chlorogenic acid was 99. 38%. Conclusion：High Chlorogenic acid transfering ratio can be gotten by uhrafiltration technique, which is helpful to the further isolation and purification of Chlorogenic acid in the subsequent process.

关 键 词：超滤膜技术 超滤 绿原酸 

分 类 号：R446.12[医药卫生—诊断学] R284.2[医药卫生—临床医学]