去甲氧基姜黄素对姜黄素稳定作用的研究  

Study on Effect of Demethoxycurcumin in Curcuma long on Stability of Curcumin

作　　者：韩刚[1] 毕瑞[1] 全乐[1] 赵琳琳[1] 董月[1] 林庆辉[1] 

机构地区：[1]华北煤炭医学院药学系/唐山市新药基础研究重点实验室,河北唐山063000

出　　处：《中药材》2008年第4期592-594,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:研究去甲氧基姜黄素对姜黄素稳定性的影响,揭示中药姜黄中存在着对姜黄素产生稳定作用的天然稳定剂。方法:以pH=8的缓冲溶液为反应介质,将去甲氧基姜黄素定量加入到姜黄素中,高效液相色谱法测定姜黄素浓度的变化,采用动力学方法建立姜黄素降解速率方程。结果:去甲氧基姜黄素、姜黄醇提取物都有助于姜黄素半衰期延长,且随着加入量的增加,姜黄素降解半衰期延长。结论:去甲氧基姜黄素在中药姜黄中对姜黄素产生稳定作用,为姜黄素天然稳定剂,在研制姜黄素制剂时,加入去甲氧基姜黄素或姜黄醇提取物,可提高姜黄素的稳定性。Objective： To investigate effect of demethoxycurcumin on stability of curcumin. Methods：To add the demethoxycurcumin to pure curcumin, the change of curcumin was determined by HPLC and the dynamics of curcumin degradation was investigated. Result：The stability both obtained from alcohol and demethoxycurcumin improved the stabilization of curcumin, the demiperiod of curcumin prolonged with the addition of demethoxycurcumin. Conclusion： The commixture of curcumin and demethoxycurcumin are more stable than pure curcumin at thesame conditions. Stability of curcumin is improved by demethoxycurcumin, it is crude stabilizing agent.

关 键 词：姜黄 去甲氧基姜黄素 去二甲氧基姜黄素 动力学 HPLC 

分 类 号：R286.02[医药卫生—中药学]