人体血糖无创测量中净信号的提取方法  

Extraction of Net Analyte Signal in the Noninvasive Blood Glucose Sensing

作　　者：刘蓉[1] 陈文亮[1] 谷筱玉[1] 徐可欣[1] 

机构地区：[1]天津大学精密测试技术及仪器国家重点实验室,天津300072

出　　处：《纳米技术与精密工程》2008年第3期207-211,共5页Nanotechnology and Precision Engineering

基　　金："十一五"国家科技支撑计划资助项目(2006BAI03A03);国家自然科学基金资助项目(30700168);中国博士后科学基金资助项目(20070410197)

摘　　要：提出了基于背景光谱构建噪声子空间提取葡萄糖净信号的方法,该方法不受参考浓度误差以及偶然相关因素的影响.对葡萄糖水溶液,以纯水为背景提取的葡萄糖净信号与传统方法的结果非常接近,相关系数达到0.9,且反映了葡萄糖的特征吸收信息.最后,在严格控制的实验条件下,对正常志愿者进行了活体口服葡萄糖耐量实验,并从生理状态不变的光谱构建的噪声子空间提取了血糖浓度变化导致的净信号.结果表明,口服葡萄糖耐量实验的漫反射光谱中的葡萄糖净信号,反映了葡萄糖分子在其一级倍频区域的特征吸收.这证实了左手掌部位采集的近红外光谱中确实携带了血糖浓度变化的信息.Based on the noise subspace spanned by the background spectra, a new method to extract the net analyte signal was proposed firstly, which was not affected by the error in reference concentration and chance correlation factors. Then, the net analyte signal of glucose aqueous solution extracted from the background spectra of pure water was quite close to that by traditional method with the correlation coefficient of 0.9, which revealed the unique absorption character of glucose. Finally, in vivo experiments of health volunteer were conducted under the well-controlled measurement conditions, and the net analyte signal of blood glucose was extracted basing on the subspace spanned by the spectra without physiological variations. Results show that, the net analyte signal of blood glucose in the near-infrared diffuse reflectance of oral glucose tolerance test reveals the unique absorption character of glucose molecule in the first overtone, which confirms the existence of the information induced by the change in blood glucose concentration in the near-infrared spectra collected from left palm.

关 键 词：近红外 葡萄糖 净信号 无创测量 

分 类 号：R446.1[医药卫生—诊断学] R318[医药卫生—临床医学]