2型糖尿病与行为和遗传因素的相关性研究  

The correlation study between behavioral and genetic factors and type 2 diabetes mellitus

作　　者：丁守华[1] 刘东 杨志寅[1] 卜志强[1] 孔令斌[1] 

机构地区：[1]济宁医学院行为医学研究所,山东省行为医学重点实验室,济宁272013 [2]山东省梁山县疾病预防控制中心

出　　处：《中国行为医学科学》2008年第5期407-409,共3页Chinese Journal of Behavioral Medical Science

摘　　要：目的研究行为、遗传因素与2型糖尿病（type 2 diabetes mellitus，T2DM）的关系，为T2DM患者制订综合预防和干预措施提供科学依据。方法采用病例对照研究方法对山东省梁山县T2DM患者（152例）及对照组（120例）核心家系进行调查，收集病例及对照组成员生活行为及一级亲属家族信息，应用单因素和多因素非条件logistic回归分析研究各因素在疾病发生中的作用，并采用Falconer法估算遗传度。结果多因素非条件logistic回归分析表明糖尿病家族史、高脂饮食、高糖饮食、体育锻炼、多食绿色蔬菜及腰臀比（WHR）等因素与T2DM之间关系有统计学意义，病例组一级亲属累积发病率为6．60％，对照组一级亲属累积发病率为1．18％，二者差异有显著性（χ^2=44．839，P〈0．01），152个家系一级亲属T2DM遗传度为57．4％。结论T2DM是遗传和行为危险因素共同作用的结果。Objective To study the relationship between behavioral, genetic factors and type 2 diabetes mellitus,and provide rational evidence for prevention and intervention of type 2 diabetes mellitus. Methods Case control study is adopted in the research, 152 cases with type 2 diabetes mellitus and 120 controls were brought into the study, collecting information of their life styles and behavior, tracing information of their first degree relatives; single and multi- factor logistic regression are applied to analyze the effect of the studying factors on type 2 diabetes mellitus. Falconer formula is adopted to estimate heritability. Results According to multi-factor logistic regression,the factors associated with type 2 diabetes mellitus include：the family history of diabetes mellitus, absorbing too much fat, enjoying sweetmeats,take exercises, eating green fresh vegetables and waist haunch ratio （WHR） et al. The cumulative incidence rate of first degree relatives in cases is 7.55% ,which is higher than that of controls （0.73%）, the difference between the two is distinctly （ χ^2 = 66.07, P〈 0.01 ）. By Falconer formula, the heritability of type 2 diabetes mellitus is 72.2% ,which indicate that heredity account for a big proportion in the occurrence of type 2 diabetes mellitus. Conclusion Type 2 diabetes mellitus is caused by the combining effects of genetic and behavior risky factors.

关 键 词：行为 遗传因素 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R193[医药卫生—内科学]