miRNAs的表达调控机制  

Mechanisms on The Regulation of miRNAs Expression

作　　者：胡士军[1] 杨增明[1] 

机构地区：[1]东北农业大学生命科学学院,哈尔滨150030

出　　处：《生物化学与生物物理进展》2008年第5期483-487,共5页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金重点资助项目(30330060)~~

摘　　要：microRNAs(miRNAs)是一类在转录后基因调控中发挥功能的非编码小RNAs,在发育、生长和分化等过程中发挥重要作用.至今已经在动物、植物和微生物等不同生物体中鉴定出来数千种miRNAs.miRNAs可以通过降解mRNA或抑制蛋白翻译的方式调节特异基因表达.生物体内约30%的基因都受miRNAs的调节.miRNAs的表达与功能受到转录因子、表观遗传学、多核苷酸多态性及其RNA编辑等多种因素的调节.此外,特异miRNA基因敲除的成功为研究miRNAs功能提供了有力的实验模型.MicroRNAs （miRNAs）, small noncoding RNAs, are essential for posttranscriptional gene regulation and have important roles in a wide range of biological processes, including development, growth and differentiation. Thousands of miRNAs have been identified in animals, plants and microoaganisms, miRNAs regulate their target genes by mRNA degradation or translation suppression. About 30 % of genes in an organism are subject to miRNA regulation, miRNA expression and function are regulated by transcriptional factors, epigenetics, single nucleotide polymorphisms, RNA editing and so on. Additionally, the success in knocking out a specific mouse miRNA gene has provided a valuable model for studying miRNA function.

关 键 词：MIRNAS 调节 敲除 

分 类 号：Q52[生物学—生物化学]