在柱水解法自动化合成^18F-氟代乙酸盐  

Automated synthesis of ^(18)F-fluoroacetate via on-column hydrolysis

作　　者：唐刚华[1] 唐小兰[2] 王明芳[1] 李葆元[1] 梁明泉[1] 王全师[1] 

机构地区：[1]南方医科大学南方医院核医学科PET中心,广州510515 [2]华南农业大学理学院,广州510642

出　　处：《核技术》2008年第5期364-368,共5页Nuclear Techniques

基　　金：广东省科技计划(2003C34304)资助

摘　　要：采用TRACERlab FXF-N自动化合成仪,以溴代乙酸苄酯为前体,经亲核氟化、在柱水解两步反应及Sep-Pak小柱分离纯化制备18F-FAC注射液。总合成时间<20 min,未校正放化产率达60%,放化纯度>95%。在柱水解法适于商售2-18F-2-脱氧-D-葡萄糖(18F-FDG)全自动化合成模块自动化合成18F-FAC。A simple and rapid automated synthetic technology of ^18F-fluoroacetate （^18F-FAC） is described in this paper. Automated synthesis of ^18F-FAC was performed by ^18F-fluorination of benzyl-2-bromoacetate as a precursor, on-column hydrolysis and Sep-Paks purification using a modifying commercial TRACERlab FXF-N synthesizer. A high and reproducible radiochemical yield of above 60% （decay uncorrected） was obtained within the whole synthesis time less than 20 min. The radiochemical purity of ^18F-FAC was 〉95%. The new, simple, and rapid on-column hydrolysis procedure should adaptable to the fully automated synthesis of ^18F-FAC at commercial FDG synthesis module.

关 键 词：^18F-氟代乙酸盐 肿瘤显像剂 在柱水解法 自动化合成 

分 类 号：R817.4[医药卫生—影像医学与核医学]