甘精胰岛素在老年危重患者合并高血糖治疗中的应用  

Effect of insulin glargine on critically ill hyperglycemia elderly patients

作　　者：楚勤英[1] 唐志雄[1] 傅小玲[1] 王进伟[1] 蒋虹[1] 贾军宏[1] 

机构地区：[1]中国人民解放军总医院第一附属医院干二科,北京100037

出　　处：《第四军医大学学报》2008年第9期859-860,共2页Journal of the Fourth Military Medical University

摘　　要：目的：观察甘精胰岛素对老年危重患者合并高血糖的降糖疗效.方法：选择老年危重患者合并高血糖患者46例,随机分为2组,治疗前两组患者24h血糖为（13.5±5.7 vs 13.2±5.9）mmol/L,治疗组（n=24）采用甘精胰岛素作为基础治疗药物,对照组（n=22）采用中性低精蛋白锌人胰岛素作为基础治疗药物.可进食患者餐前追加短效胰岛素.血糖控制目标为5.0～8.0mmol/L.结果：治疗组1,3,5d的平均血糖较对照组降低,分别为（13.5±5.7vs13.2±5.9）mmol/L,P〈0.01,（7.5±0.8vs10.5±1.7）mmol/L,P〈0.01,（5.9±1.1vs6.5±0.8）mmol/L,P〈0.05.7d及以后,两组间血糖无统计学差异.结论：以甘精胰岛素为基础胰岛素的治疗方案能有效控制老年危重合并高血糖患者的血糖水平,值得临床推广应用.AIM： To investigate the efficacy of insulin glargine on critically ill hyperglycemia elderly patients. METHODS： Forty-eight critically ill elderly inpatients complicated with hyperglycemia were enrolled into this trail. They were divided into 2 groups, insulin glargine treatment group and insulin glargine treatment group. The control level of blood glucose and hypoglycemia occurrence after treatment were detected. RESULTS： The level of blood glucose after treatment was obviously decreased in insulin glargine treatment group and insulin glargine treatment group, but blood glucose level in insulin glargine treatment group decreased more on the 1st, 3 rd and 5th day[ （13.5 ±5.7 vs 13.2 ±5.9） mmol/L, P〈0.01; （7.5 ±0.8 vs 10.5 ±1.7） mmol/L, P〈0.01; （5.9±1.1 vs6.5±0.8） mmol/L, P〈0.05]. CONCLUSION： Insulin glargine is an effective and safe drug for critically ill elderly inpatients with hyperglycemia.

关 键 词：甘精胰岛素 高血糖 老年人 

分 类 号：R587[医药卫生—内分泌]