中药复方对肝炎病毒抑制影响的血清药理学研究  

Chinese medicinal compound Yinzhiku significantly inhibits hepatitis virus

作　　者：干振华[1] 李金恒[2] 

机构地区：[1]南方医科大学南京临床学院(南京军区南京总医院)医务部,江苏南京210002 [2]南方医科大学南京临床学院(南京军区南京总医院)药理科,江苏南京210002

出　　处：《医学研究生学报》2008年第5期455-457,共3页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30472055)

摘　　要：目的:评价茵栀苦复方的抗肝炎药效,为临床应用提供药效学依据。方法:借助HepG2.2.15细胞模型,以血清药理学方法,测定水提物血清和醇提物血清对HbsAg、HbeAg的抑制率。结果:①两种药物血清对HepG2.2.15细胞上清分泌的HBsAg抑制率在第6 d达到最高峰,此后逐渐下降,但到第12 d仍然可测到较高的水平。②两种药物血清对HepG2.2.15细胞上清分泌的HBeAg抑制率第6 d达到最高峰,此后无明显下降,到第12 d抑制率仍维持在较高、较稳定的水平。结论:组方的水提取物和醇提取物都对HbsAg、HbeAg具有很高的抑制率,两者之间无明显差异。Objective： To evaluate the anti-hepatitis effect of Yinzhiku Compound and obtain pharmacodynamic evidence for its clinical application. Methods ： Using the model of HepG2.2.15 cells, we determined the inhibitory effects of the drug extract with water and that with alcohol on HbsAg and HbeAg from the HepG2.2.15 cells by serum pharmacological methods. Results ： The inhibition of the two abstracts on HbsAg reached the peak on the sixth day and gradually dropped afterwards, but still at a high level on the twelfth day. Their inhibitory effect on HbeAg, too, attained the highest level on the sixth day, but did not fall obviously afterwards and remained high even on the twelfth day. Conclusion： Yinzhiku Compound has a high inhibitory effect on both HbsAg and HbeAg, with no evident difference between the drug extract with water and that with alcohol.

关 键 词：中药复方 水提取物 醇提取物 血清药理学 

分 类 号：R285.1[医药卫生—中药学]