速效抗晕胶囊急性毒性实验研究  

Research on acute toxicity of quick-effective anti-motion capsule

作　　者：李珂娴[1] 蒋定文[1] 范正平[1] 储智勇[1] 雷呈祥[1] 沈先荣[1] 

机构地区：[1]海军医学研究所防护医学研究室,上海200433

出　　处：《中华航海医学与高气压医学杂志》2008年第2期97-98,共2页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：总后科研基金项目（06A202）

摘　　要：目的观察速效抗晕胶囊对小鼠的急性毒性表现以评价药物的安全性。方法通过对ICR小鼠单次灌胃观察速效抗晕胶囊对小鼠的急性毒性表现，根据死亡率用综合分析法计算药物的半致死剂量（LD50）值。结果小鼠服药后呈现与浓度正相关的兴奋性神经症状。症状初始时间为服药后10min左右，高浓度组（1461．6mg／kg）小鼠快速死亡，死亡时间集中在1～2h。速效抗晕胶囊对小鼠的LD50为1043．3mg／kg，LD50的95％可信区间为972．8～1113．8mg／kg。结论速效抗晕胶囊灌胃给药小鼠的LD50为1043．3mg／kg，相当于临床推荐剂量的298～596倍。Objective To observe and determine the medial lethal dose （ LDso ） of quick-effective antimotion capsule for mice to evaluate it＇ s safety. Methods The toxicity response of ICR mice were observed and recorded after the mice were lavaged with the capsule once. LD50 and 95% reliability limit were calculated by aggregate analysis according to death rate. Results The mice showed exciting nerval syndrome with a positive correlation to the medicine concentration. The earliest syndrome emerged about 10 vain after treatment. The mice in the high dosage groups died quickly and the death time focused within 1-2 h. LD50 of quick-effective anti-motion capsule for mice was 1043.3 mg/kg, 95% reliability limi of LD50 was 972.8-1113.8 mg/kg. Conclusions LD40 of quick-effective anti-motion capsule for mice is 1043.3 mg/kg, which is 298-596 times of recommended clinic dosage.

关 键 词：速效抗晕胶囊 急性毒性 半致死剂量 运动病 

分 类 号：R686[医药卫生—骨科学]