多发性硬化患者视力障碍与磁共振图像胼胝体纹理特征研究  

Study on Relations of Visual Disturbance and Corpus Callosum's Splenium Texture in Conventional Magnetic Resonance Images for Multiple Sclerosis Based on Logistic Regression Model

作　　者：童忠勇[1] 于春水[2] 童隆正[1] 

机构地区：[1]首都医科大学生物医学工程学院,北京100069 [2]首都医科大学宣武医院放射科,北京100053

出　　处：《中国医疗设备》2008年第4期13-14,29,共3页China Medical Devices

基　　金：国家自然科学基金(30670575);北京市自然科学基金(3073015)

摘　　要：目的研究多发性硬化(MS)视力障碍患者胼胝体压部常规磁共振图像纹理特征。方法从13例临床表现视力障碍和19例视力正常的MS患者常规磁共振矢状位T1加权图像胼胝体压部表现正常部位提取感兴趣区,组成视力障碍组和对照组样本集;经灰度共生矩阵、灰度梯度共生矩阵映射,提取纹理参数;建立逻辑回归模型,测试临床表现视力障碍MS患者胝体压部的纹理特征。结果研究结果显示,胝体压部图像的差均值(OR=4.053,P=0.034)和灰度均方差(OR=0.371,P=0.021)与临床表现视力障碍有关。结论有视力障碍的MS患者与无视力障碍患者胼胝体压部MRI纹理特征不同。图像纹理分析方法可能为揭示MS隐匿性病变提供新方法。Objective The aim of this study is to explore the texture characteristics of splenium of corpus callosum in conventional magnetic resonance images （cMRI） from multiple sclerosis （MS） patients with visual disturbance. Methods Firstly, the sagittal Tl-weighted MR images were selected from thirteen relapsing-remitting MS patients with visual disturbance and other nineteen patients with normal vision. Secondly, regions of interest （ROI） were extracted from these images in splenium of normal appearing corpus callosum, composing a visual disturbance group and a normal visual group respectively. All of the ROIs were then mapped into gray level co-occurrence matrix and gray gradient level co-occurrence matrix in turn, followed by texture characteristic extraction. Finally, logistic regression model was employed in analyzing the texture characteristics based on multivariable regression analysis. Results Significant correlation was shown in both difference average （OR=4.053, P=0.034） and mean square deviation of gray level （OR=0.371, P=0.021） with visual disturbance of patients with MS. Conclusion There were differences in the texture characteristics of splenium in MR images between MS patients with visual disturbance and those with normal vision. It is suggested that hidden abnormality of patients with MS might be revealed by texture analysis.

关 键 词：多发性硬化 MRI MR扫描仪 视力障碍 胼胝体压部 

分 类 号：R445.2[医药卫生—影像医学与核医学]