电刺激大鼠疑核对胸腺中胸腺素和TGF-β mRNA水平的影响  

Effects of Acute Electrical Stimulation of Rat Nucleus Ambiguus on the Expression of TGF-β,Thymosin in Thymus and the Release of IL2,IL-6 in Splenocytes

作　　者：梅英武[1] 杨占清[1] 王玮[1] 尹秀玲[2] 柳巨雄[1] 

机构地区：[1]吉林大学农学部畜牧兽医学院,长春130062 [2]河北北方学院,张家口075031

出　　处：《吉林农业大学学报》2008年第2期184-187,共4页Journal of Jilin Agricultural University

基　　金：国家自然科学基金项目(30671535)

摘　　要：通过急性电刺激大鼠疑核,利用Real-time PCR方法研究了胸腺中胸腺素、TGF-βmRNA在刺激前后的变化规律。结果表明:急性电刺激大鼠疑核后,胸腺中胸腺素与内参的比值从(1.46±0.98)×10-6降低至(2.65±0.31)×10-7,TGF-βmRNA从(3.67±0.86)×10-6降低至(1.92±0.66)×10-7,电刺激组mRNA水平明显低于假刺激对照组。研究结果提示,疑核对大鼠胸腺组织的功能有重要的调节作用。We studied the effect of acute electrical stimulation of Arab on the levels of TGF-β and thymosin-β4 rnRNA in thymus. We found that The rnRNA level of thymosin and TGF-β3 were all significantly decreased from （1.46 ± 0.98） × 10^-6 to （2.65± 0.31） × 10^-7 and from （3.67 ± 0.86）× 10^-6 to （1.92 ± 0.66） × 10^-7 following the effective Amb-stimulation in comparison with those of sham-stimulation groups. These findings reveal that the Amb participates in the modulation of animal immune functions.

关 键 词：大鼠 神经免疫调节 电刺激 疑核 

分 类 号：R392[医药卫生—免疫学]